Literature DB >> 1349865

The influence of chronic nicotine treatment on stress-induced gastric ulceration and emptying rate in rats.

B S Qiu1, C H Cho, C W Ogle.   

Abstract

Ten-day treatment with nicotine (5, 25 or 50 micrograms/ml drinking water) dose-dependently intensified gastric ulceration induced by cold-restraint, and emptying rate. Stomach contractions produced by graded doses of bethanechol i.v. were elevated further by nicotine treatment. It is suggested that chronic nicotine administration produces hypersensitivity of the gastric muscarinic receptors; stomach hypermotility contributes to the ulcer-worsening action of the alkaloid.

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Year:  1992        PMID： 1349865     DOI： 10.1007/bf01923437

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  Pathogenesis of acute gastric stress ulcers.

Authors:  H Goldman; C B Rosoff
Journal:  Am J Pathol       Date:  1968-01       Impact factor: 4.307

2.  Studies of the mechanisms involved in the production of stress and stress-atropine ulcers in rats.

Authors:  K Takagi; S Okabe
Journal:  Eur J Pharmacol       Date:  1970       Impact factor: 4.432

3.  Effects of ethanol and nicotine on gastrin and somatostatin release in rats.

Authors:  C H Cho; C W Ogle; S H Wong; S K Lam
Journal:  Horm Res       Date:  1987

4.  The effect of nicotine pretreatment on the gastric mucosal damage induced by aspirin and reserpine in rats.

Authors:  A M Ageel; N S Parmar; M Tariq
Journal:  Life Sci       Date:  1984-02-20       Impact factor: 5.037

5.  Role of gastric motility in development of stress-induced gastric lesions of rats.

Authors:  S Yano; M Akahane; M Harada
Journal:  Jpn J Pharmacol       Date:  1978-08

6.  Some pharmacological factors involved in formation and prevention of stress ulcer in rats.

Authors:  K Watanabe
Journal:  Chem Pharm Bull (Tokyo)       Date:  1966-02       Impact factor: 1.645

7.  The effect of nicotine on ethanol-induced gastric ulcers in rats.

Authors:  C W Ogle; C H Cho; S H Wong
Journal:  Experientia       Date:  1985-09-15

8.  Chronic nicotine treatment intensifies gastric ulceration by cold-restraint stress in rats.

Authors:  B S Qiu; C H Cho; C W Ogle
Journal:  Agents Actions       Date:  1991-07

Review 9.  Clinical pharmacology of nicotine.

Authors:  N L Benowitz
Journal:  Annu Rev Med       Date:  1986       Impact factor: 13.739

10.  A correlative study of the antiulcer effects of zinc sulphate in stressed rats.

Authors:  C H Cho; C W Ogle
Journal:  Eur J Pharmacol       Date:  1978-03-01       Impact factor: 4.432
  10 in total
  4 in total

1.  The influence of peripheral or central administration of ondansetron on stress-induced gastric ulceration in rats.

Authors:  C W Ogle; S C Hui
Journal:  Experientia       Date:  1995-08-16

2.  Acute effect of nicotine patch on gastric emptying of liquid and solid contents in healthy subjects.

Authors:  P W Wong; S C Kadakia; M McBiles
Journal:  Dig Dis Sci       Date:  1999-11       Impact factor: 3.199

3.  Effects of nitric oxide on gastric ulceration induced by nicotine and cold-restraint stress.

Authors:  Bo-Sheng Qui; Qi-Bing Mei; Li Liu; Kam-Meng Tchou-Wong
Journal:  World J Gastroenterol       Date:  2004-02-15       Impact factor: 5.742

Review 4.  Smoking and the pathogenesis of gastroduodenal ulcer--recent mechanistic update.

Authors:  Pallab Maity; Kaushik Biswas; Somenath Roy; Ranajit K Banerjee; Uday Bandyopadhyay
Journal:  Mol Cell Biochem       Date:  2003-11       Impact factor: 3.396
  4 in total

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