Literature DB >> 1349580

Human-mouse homologies in the region of the polycystic kidney disease gene (PKD1).

H Himmelbauer1, M Pohlschmidt, A Snarey, G G Germino, D Weinstat-Saslow, S Somlo, S T Reeders, A M Frischauf.   

Abstract

Autosomal dominant polycystic kidney disease (PKD1) is linked to the alpha-globin locus near the telomere of chromosome 16p. We established the existence of a conserved linkage group in mouse by mapping conserved sequences and cDNAs from the region surrounding the PKD1 gene in the mouse genome. Results obtained with the BXD recombinant strain system and somatic cell hybrids show the homologous region to be located on mouse chromosome 17 near the globin pseudogene Hba-ps4, an unprocessed alpha-like globin gene. The markers we mapped are widely distributed over the region known to contain the PKD1 gene, and it is therefore likely that the mouse homologue of PKD1 is also located on mouse chromosome 17.

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Year:  1992        PMID： 1349580     DOI： 10.1016/0888-7543(92)90198-2

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  11 in total

1.  Comparative analysis of the alpha-like globin clusters in mouse, rat, and human chromosomes indicates a mechanism underlying breaks in conserved synteny.

Authors:  Cristina Tufarelli; Ross Hardison; Webb Miller; Jim Hughes; Kevin Clark; Nicki Ventress; Anna Maria Frischauf; Douglas R Higgs
Journal:  Genome Res       Date:  2004-04       Impact factor: 9.043

Review 2.  Mouse chromosome 17.

Authors:  L M Silver; K Artzt; D Barlow; K Fischer-Lindahl; M F Lyon; J Klein; L Snyder
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

3.  The cld mutation: narrowing the critical chromosomal region and selecting candidate genes.

Authors:  Miklós Péterfy; Hui Z Mao; Mark H Doolittle
Journal:  Mamm Genome       Date:  2006-10-03       Impact factor: 2.957

4.  A genetic, physical, and comparative map of rat chromosome 10.

Authors:  R S Yeung; K H Buetow; T Scherpbier-Heddema; D W Bell; J R Testa
Journal:  Mamm Genome       Date:  1996-06       Impact factor: 2.957

5.  Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice.

Authors:  R J Rooney; R R Daniels; N A Jenkins; D J Gilbert; K Rothammer; S W Morris; D R Higgs; N G Copeland
Journal:  Mamm Genome       Date:  1998-04       Impact factor: 2.957

6.  Mapping around the Fused locus on mouse chromosome 17.

Authors:  H F Sutherland; E Pick; F Francis; H Lehrach; A M Frischauf
Journal:  Mamm Genome       Date:  1995-07       Impact factor: 2.957

7.  Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10.

Authors:  R S Yeung; K H Buetow; J R Testa; A G Knudson
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-01       Impact factor: 11.205

8.  Genetic mapping of the polycystic kidney gene, pcy, on mouse chromosome 9.

Authors:  S Nagao; T Watanabe; N Ogiso; T Marunouchi; H Takahashi
Journal:  Biochem Genet       Date:  1995-12       Impact factor: 1.890

9.  Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3.

Authors:  M Centola; X Chen; R Sood; Z Deng; I Aksentijevich; T Blake; D O Ricke; X Chen; G Wood; N Zaks; N Richards; D Krizman; E Mansfield; S Apostolou; J Liu; N Shafran; A Vedula; M Hamon; A Cercek; T Kahan; D Gumucio; D F Callen; R I Richards; R K Moyzis; N A Doggett; F S Collins; P P Liu; N Fischel-Ghodsian; D L Kastner
Journal:  Genome Res       Date:  1998-11       Impact factor: 9.043

Review 10.  Mouse homologues of human hereditary disease.

Authors:  A G Searle; J H Edwards; J G Hall
Journal:  J Med Genet       Date:  1994-01       Impact factor: 6.318
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