Literature DB >> 1349483

The role of cell division in the induction of clonal anergy.

M K Jenkins1.   

Abstract

The interaction of antigen with lymphocyte antigen receptors can result in either clonal expansion or unresponsiveness (anergy). In 1970, Bretscher and Cohn proposed a two-signal model of lymphocyte activation to explain this paradox: antigen receptor occupancy alone could induce unresponsiveness whereas antigen receptor occupancy plus a costimulatory signal could induce immunity. Here, Marc Jenkins reviews in vitro and in vivo manifestations of clonal anergy and evaluates the ability of the two-signal model to explain these phenomena.

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Year:  1992        PMID： 1349483     DOI： 10.1016/0167-5699(92)90137-V

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  40 in total

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Review 3.  The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism.

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4.  Compensation for decreased expression of B7 molecules on Leishmania infantum-infected canine macrophages results in restoration of parasite-specific T-cell proliferation and gamma interferon production.

Authors:  E Pinelli; V P Rutten; M Bruysters; P F Moore; E J Ruitenberg
Journal:  Infect Immun       Date:  1999-01       Impact factor: 3.441

Review 5.  TNF superfamily: costimulation and clinical applications.

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6.  Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes.

Authors:  B Hofmann; P Nishanian; T Nguyen; P Insixiengmay; J L Fahey
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Review 7.  mTOR: taking cues from the immune microenvironment.

Authors:  Greg M Delgoffe; Jonathan D Powell
Journal:  Immunology       Date:  2009-08       Impact factor: 7.397

8.  The costimulatory signal CD28 is fully functional but cannot correct the impaired antigen response in T cells of patients with common variable immunodeficiency.

Authors:  M B Fischer; H M Wolf; H Eggenbauer; V Thon; E Vogel; J Lokaj; J Litzman; J W Mannhalter; M M Eibl
Journal:  Clin Exp Immunol       Date:  1994-02       Impact factor: 4.330

9.  'Subthreshold stimulation' of allospecific delayed hypersensitivity by corneal allografts.

Authors:  J Y Niederkorn; E Mayhew
Journal:  Immunology       Date:  1993-12       Impact factor: 7.397

10.  B7/BB-1 is a leucocyte differentiation antigen on human dendritic cells induced by activation.

Authors:  D N Hart; G C Starling; V L Calder; N S Fernando
Journal:  Immunology       Date:  1993-08       Impact factor: 7.397
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