Literature DB >> 13489662

Pharmacological and initial therapeutic observations on 6-diazo-5-oxo-1-norleucine (DON) in human neoplastic disease.

G B MAGILL, W P MYERS, H C REILLY, R C PUTNAM, J W MAGILL, M P SYKES, G C ESCHER, D A KARNOFSKY, J H BURCHENAL.   

Abstract

Entities:  

Keywords:  CYTOTOXIC DRUGS; LEUCINE/related compounds

Mesh：

Substances：

Year:  1957        PMID： 13489662     DOI： 10.1002/1097-0142(195711/12)10:6<1138::aid-cncr2820100608>3.0.co;2-k

Source DB:  PubMed          Journal:  Cancer        ISSN： 0008-543X            Impact factor:   6.860


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  27 in total

1.  Chemotherapy of solid cancer arising from the gastro-intestinal tract.

Authors:  J D HURLEY; E H ELLISON
Journal:  Ann Surg       Date:  1960-10       Impact factor: 12.969

2.  Studies of the uricogenic effect of 2-substituted thiadiazoles in man.

Authors:  I H KRAKOFF; M E BALIS
Journal:  J Clin Invest       Date:  1959-06       Impact factor: 14.808

3.  Suppression of uric acid synthesis in the gouty human by the use of 6-diazo-5-oxo-L-norleucine.

Authors:  A I GRAYZEL; J E SEEGMILLER; E LOVE
Journal:  J Clin Invest       Date:  1960-03       Impact factor: 14.808

Review 4.  Targeting Cancer Metabolism and Current Anti-Cancer Drugs.

Authors:  Witchuda Sukjoi; Jarunya Ngamkham; Paul V Attwood; Sarawut Jitrapakdee
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

5.  Glutamine targeting inhibits systemic metastasis in the VM-M3 murine tumor model.

Authors:  Laura M Shelton; Leanne C Huysentruyt; Thomas N Seyfried
Journal:  Int J Cancer       Date:  2010-11-15       Impact factor: 7.396

6.  Evaluating the Analgesic Effect of the GLS Inhibitor 6-Diazo-5-Oxo-L-Norleucine in Vivo.

Authors:  Heith A Crosby; Kenneth E Miller
Journal:  Pharm Pharmacol Int J       Date:  2016-01-08

7.  Tumor-Targeted Delivery of 6-Diazo-5-oxo-l-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs.

Authors:  Lukáš Tenora; Jesse Alt; Ranjeet P Dash; Alexandra J Gadiano; Kateřina Novotná; Vijayabhaskar Veeravalli; Jenny Lam; Quinn R Kirkpatrick; Kathryn M Lemberg; Pavel Majer; Rana Rais; Barbara S Slusher
Journal:  J Med Chem       Date:  2019-03-29       Impact factor: 7.446

8.  Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion.

Authors:  Robert D Leone; Liang Zhao; Judson M Englert; Im-Meng Sun; Min-Hee Oh; Im-Hong Sun; Matthew L Arwood; Ian A Bettencourt; Chirag H Patel; Jiayu Wen; Ada Tam; Richard L Blosser; Eva Prchalova; Jesse Alt; Rana Rais; Barbara S Slusher; Jonathan D Powell
Journal:  Science       Date:  2019-11-07       Impact factor: 47.728

9.  Evaluating the Toxicity of the Analgesic Glutaminase Inhibitor 6-Diazo-5-Oxo-L-Norleucine in vitro and on Rat Dermal Skin Fibroblasts.

Authors:  Heith A Crosby; Michael Ihnat; Kenneth E Miller
Journal:  MOJ Toxicol       Date:  2015-03-25

10.  Phase I study and clinical pharmacology of 6-diazo-5-oxo-L-norleucine (DON).

Authors:  A Rahman; F P Smith; P T Luc; P V Woolley
Journal:  Invest New Drugs       Date:  1985       Impact factor: 3.850
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