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Literature DB >> 13481245

Studies on the pathogenesis of fever. IX. Characteristics of endogenous serum pyrogen and mechanisms governing its release.

Abstract

The "endogenous serum pyrogen" that appears in the circulating blood after a single intravenous injection of endotoxin does not produce leukopenia in normal animals, fails to provoke the local Shwartzman reaction, and elicits no "tolerance" when injected daily. Suppression of the febrile response to endotoxin by prednisone does not prevent the appearance of pyrogen in the blood. Animals given large amounts of endotoxin daily continue to respond with high fevers despite failure of endogenous serum pyrogen to appear in detectable amounts after the first two or three injections. Analysis of the response to daily injections shows clearly that the fever during the first 2 hours after administration of endotoxin is unrelated to levels of endogenous serum pyrogen; in contrast, the magnitude of the fever after the 2nd hour correlates well with endogenous pyrogen in some instances. The leukopenic response to endotoxin could not be correlated with the appearance of endogenous serum pyrogen. The differences between endotoxin and endogenous pyrogen and the similarities between leukocyte extracts (sterile exudates) and endogenous pyrogen are summarized and discussed. Dissociation of the febrile response to bacterial endotoxin and levels of endogenous serum pyrogen are discussed and it is concluded that a mechanism involving both direct and indirect action of endotoxins offers the best explanation for the pyrogenic action of these bacterial products.

Entities: Chemical Disease

Keywords: FEVER/etiology and pathogenesis

Mesh：

Substances：

Year: 1957 PMID： 13481245 PMCID： PMC2136831 DOI： 10.1084/jem.106.6.787

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

18 in total

1. Studies on the pathogenesis of fever. VI. The effect of heat on endogenous and exogenous pyrogen in the serum of dogs.

Authors: R G PETERSDORF; I L BENNETT
Journal: Bull Johns Hopkins Hosp Date: 1957-05

2. Studies on the pathogenesis of fever. VII. Comparative observations on the production of fever by inflammatory exudates in rabbits and dogs.

Authors: R G PETERSDORF; I L BENNETT
Journal: Bull Johns Hopkins Hosp Date: 1957-06

3. Studies on the pathogenesis of fever. VIII. Fever-producing substances in the serum of dogs.

Authors: R G PETERSDORF; I L BENNETT
Journal: J Exp Med Date: 1957-08-01 Impact factor: 14.307

4. The effect of hydrocortisone and of piromen in vitro on leukocytes of patients receiving ACTH and cortisone therapy.

Authors: G P KERBY; J A BARRETT
Journal: J Clin Invest Date: 1954-05 Impact factor: 14.808

5. The effect of cortisone upon reactions of rabbits to bacterial endotoxins with particular reference to acquired resistance.

Authors: I L BENNETT; P B BEESON
Journal: Bull Johns Hopkins Hosp Date: 1953-11

6. Latency of pyrogen fever; appearance of a fast-acting pyrogen in the blood of febrile animals and in plasma incubated with bacterial pyrogen.

Authors: R GRANT; W J WHALEN
Journal: Am J Physiol Date: 1953-04

7. Studies on the pathogenesis of fever. II. Identification of an endogenous pyrogen in the blood stream following the injection of typhoid vaccine.

Authors: E ATKINS; W B WOOD
Journal: J Exp Med Date: 1955-11-01 Impact factor: 14.307

8. Studies on the pathogenesis of fever. II. Characterization of fever-producing substances from polymorphonuclear leukocytes and from the fluid of sterile exudates.

Authors: I L BENNETT; P B BEESON
Journal: J Exp Med Date: 1953-11 Impact factor: 14.307

9. Studies of the effect of bacterial endotoxins on rabbit leucocytes. I. Effect of intravenous injection of the substances with and without induction of the local Shwartzman reaction.

Authors: M BERTHRONG; L E CLUFF
Journal: J Exp Med Date: 1953-10 Impact factor: 14.307

10. Studies on the pathogenesis of fever. I. The effect of injection of extracts and suspensions of uninfected rabbit tissues upon the body temperature of normal rabbits.

Authors: I L BENNETT; P B BEESON
Journal: J Exp Med Date: 1953-11 Impact factor: 14.307

24 in total

1. Studies on the pathogenesis of fever. VIII. Further observations on the role of endogenous pyrogen in endotoxin fever.

Authors: S M GILLMAN; D L BORNSTEIN; W B WOOD
Journal: J Exp Med Date: 1961-11-01 Impact factor: 14.307

10. Studies on pyrogenic steroids. I. Separation, identification, and measurement of unconjugated dehydroepiandrosterone, etiocholanolone, and adrosterone in human plasma.

Authors: G L COHN; P K BONDY; C CASTIGLIONE
Journal: J Clin Invest Date: 1961-02 Impact factor: 14.808

Studies on the pathogenesis of fever. IX. Characteristics of endogenous serum pyrogen and mechanisms governing its release.

1. Studies on the pathogenesis of fever. VI. The effect of heat on endogenous and exogenous pyrogen in the serum of dogs.

2. Studies on the pathogenesis of fever. VII. Comparative observations on the production of fever by inflammatory exudates in rabbits and dogs.

3. Studies on the pathogenesis of fever. VIII. Fever-producing substances in the serum of dogs.

4. The effect of hydrocortisone and of piromen in vitro on leukocytes of patients receiving ACTH and cortisone therapy.

5. The effect of cortisone upon reactions of rabbits to bacterial endotoxins with particular reference to acquired resistance.

6. Latency of pyrogen fever; appearance of a fast-acting pyrogen in the blood of febrile animals and in plasma incubated with bacterial pyrogen.

7. Studies on the pathogenesis of fever. II. Identification of an endogenous pyrogen in the blood stream following the injection of typhoid vaccine.

8. Studies on the pathogenesis of fever. II. Characterization of fever-producing substances from polymorphonuclear leukocytes and from the fluid of sterile exudates.

9. Studies of the effect of bacterial endotoxins on rabbit leucocytes. I. Effect of intravenous injection of the substances with and without induction of the local Shwartzman reaction.

10. Studies on the pathogenesis of fever. I. The effect of injection of extracts and suspensions of uninfected rabbit tissues upon the body temperature of normal rabbits.

1. Studies on the pathogenesis of fever. VIII. Further observations on the role of endogenous pyrogen in endotoxin fever.

2. [The mode of action of pyrogens and bacterial endotoxins].

3. Observations on the pyrogenic response and its application to the bioassay of endotoxin.

4. Pathogenesis of Fever.

5. Gordon Wilson Lecture. Fever: Experimental Studies.

Review 6. [Virus-induced fever. (Results and problems)].

7. The pathophysiological effect of scarlet fever toxin. I. Its effect on the white blood picture.

8. [Induction of endogenous pyrogen and interferon by Newcastle disease virus in vivo].

9. STUDIES IN STAPHYLOCOCCAL FEVER. II. RESPONSES TO CULTURE FILTRATES.

10. Studies on pyrogenic steroids. I. Separation, identification, and measurement of unconjugated dehydroepiandrosterone, etiocholanolone, and adrosterone in human plasma.