Literature DB >> 1348050

Two intragenic polymorphisms of the APC-gene detected by PCR and enzymatic digestion.

C Kraus1, W G Ballhausen.   

Abstract

The gene causing adenomatous polyposis coli (APC) has recently been cloned. Three intragenic polymorphisms were reported to be detectable by single-strand conformation polymorphism analysis. Here, we describe an assay using polymerase-chain-reaction-based amplification and subsequent enzymatic digestion of genomic sequences to identify polymorphic sites at nucleotide positions 1458 and 5037 of the APC gene.

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Year:  1992        PMID： 1348050     DOI： 10.1007/bf02265305

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  2 in total

1.  Identification of deletion mutations and three new genes at the familial polyposis locus.

Authors:  G Joslyn; M Carlson; A Thliveris; H Albertsen; L Gelbert; W Samowitz; J Groden; J Stevens; L Spirio; M Robertson
Journal:  Cell       Date:  1991-08-09       Impact factor: 41.582

2.  Identification and characterization of the familial adenomatous polyposis coli gene.

Authors:  J Groden; A Thliveris; W Samowitz; M Carlson; L Gelbert; H Albertsen; G Joslyn; J Stevens; L Spirio; M Robertson
Journal:  Cell       Date:  1991-08-09       Impact factor: 41.582
  2 in total
  8 in total

1.  Identification of an alternative 5' untranslated region of the adenomatous polyposis coli gene.

Authors:  S Lambertz; W G Ballhausen
Journal:  Hum Genet       Date:  1993-02       Impact factor: 4.132

2.  Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas.

Authors:  O M Sieber; H Lamlum; M D Crabtree; A J Rowan; E Barclay; L Lipton; S Hodgson; H J W Thomas; K Neale; R K S Phillips; S M Farrington; M G Dunlop; H J Mueller; M L Bisgaard; S Bulow; P Fidalgo; C Albuquerque; M I Scarano; W Bodmer; I P M Tomlinson; K Heinimann
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-26       Impact factor: 11.205

3.  Screening by genomic linkage studies and mutation analysis of hereditary adenomatous polyposis coli: usefulness for clinical practice.

Authors:  J Karner-Hanusch; B Wolf; M Zehetmayer; F Wrba; E Roth; C Mannhalter
Journal:  World J Surg       Date:  1996-06       Impact factor: 3.352

4.  Evaluation of molecular genetic diagnosis in the management of familial adenomatous polyposis coli: a population based study.

Authors:  E R Maher; D E Barton; R Slatter; D J Koch; M H Jones; H Nagase; S J Payne; S J Charles; A T Moore; Y Nakamura
Journal:  J Med Genet       Date:  1993-08       Impact factor: 6.318

5.  Familial adenomatous polyposis: a submicroscopic deletion at the APC locus in a family with mentally normal patients.

Authors:  M Mandl; R Caspari; A Jauch; T Böker; H Raschke; M Sengteller; P Propping; W Friedl
Journal:  Hum Genet       Date:  1996-02       Impact factor: 4.132

6.  Rapid detection of rare variants and common polymorphisms in the APC gene by PCR-SSCP for presymptomatic diagnosis and showing allele loss.

Authors:  S A Gayther; R Sud; D Wells; K Tsioupra; J D Delhanty
Journal:  J Med Genet       Date:  1995-07       Impact factor: 6.318

7.  Infrequent alterations of the APC and MCC genes in gastric cancers from British patients.

Authors:  R Sud; I C Talbot; J D Delhanty
Journal:  Br J Cancer       Date:  1996-10       Impact factor: 7.640

8.  State of adenomatous polyposis coli gene and ras oncogenes in Japanese prostate cancer.

Authors:  H Suzuki; S Aida; S Akimoto; T Igarashi; R Yatani; J Shimazaki
Journal:  Jpn J Cancer Res       Date:  1994-08
  8 in total

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