Literature DB >> 1348012

Production and characterization of a murine/human chimeric anti-idiotype antibody that mimics ganglioside.

A Hastings1, S L Morrison, S Kanda, R E Saxton, R F Irie.   

Abstract

The VL and VH from a murine anti-idiotypic antibody that mimics ganglioside have been cloned, sequenced, and expressed as a chimeric mouse/human IgG1 antibody. The chimeric antibody retained a binding specificity indistinguishable from the original murine antibody. The VH was a member of Vgam 3.8 family. The sequences are discussed in terms of ways in which proteins may mimic ganglioside epitopes.

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Year:  1992        PMID： 1348012

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  3 in total

1.  In vitro and in vivo antitumor activity of a chimeric anti-CD19 antibody.

Authors:  G A Pietersz; L Wenjun; V R Sutton; J Burgess; I F McKenzie; H Zola; J A Trapani
Journal:  Cancer Immunol Immunother       Date:  1995-07       Impact factor: 6.968

2.  Vectors for the expression of PCR-amplified immunoglobulin variable domains with human constant regions.

Authors:  M A Walls; K C Hsiao; L J Harris
Journal:  Nucleic Acids Res       Date:  1993-06-25       Impact factor: 16.971

3.  Both VH and VL regions contribute to the antigenicity of anti-idiotypic antibody that mimics melanoma associated ganglioside GM3.

Authors:  S Kanda; H Takeyama; Y Kikumoto; S L Morrison; D L Morton; R F Irie
Journal:  Cell Biophys       Date:  1994
  3 in total

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