| Literature DB >> 1347908 |
Abstract
Continuous dopaminergic stimulation has been shown to stabilize motor fluctuations in patients with advanced Parkinson's disease (PD) who do not respond to more conventional forms of therapy. Levodopa infusions confer immediate benefit as a direct result of maintaining steady plasma levodopa concentrations. Fluctuations of synaptic dopamine inherent in the usual oral treatment of PD might result in deleterious postsynaptic changes. Some of these presumed receptor alterations might revert as a consequence of continuous levodopa infusion.Entities:
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Year: 1992 PMID： 1347908
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910