Literature DB >> 13475385

Collagen biosynthesis; tissue culture experiments to ascertain the role of ascorbic acid in collagen formation.

J F WOESSNER, B S GOULD.   

Abstract

Quantitative studies of collagen formation by chick embryonic lung tissue grown in media deficient in, or completely lacking, ascorbic acid have been carried out. Cell growth and collagen formation in such cultures can proceed almost normally in media lacking ascorbic acid. Ascorbic acid in combination with whole embryo extract, dialyzed media, or synthetic mixture number 703 was found to have no appreciable effect on cell growth or total collagen formation. This is in marked contrast to the almost total failure of collagen formation in scorbutic animals and suggests that for slow collagen biosynthesis as distinct from more prolific collagen-producing systems, ascorbic acid plays an indirect role.

Entities:  

Keywords:  COLLAGEN; VITAMIN C/effects

Mesh：

Substances：

Year:  1957        PMID： 13475385      PMCID： PMC2224114          DOI： 10.1083/jcb.3.5.685

Source DB:  PubMed          Journal:  J Biophys Biochem Cytol        ISSN： 0095-9901


  12 in total

1.  A rapid, simple method for the determination of reduced, dehydro-, and total ascorbic acid in biological material.

Authors:  R R SCHAFFERT; G R KINGSLEY
Journal:  J Biol Chem       Date:  1955-01       Impact factor: 5.157

2.  Nutrition of animal cells in tissue culture. IX. Synthetic medium No. 703.

Authors:  G M HEALY; D C FISHER; R C PARKER
Journal:  Can J Biochem Physiol       Date:  1954-05

3.  The effect of cortisone on collagen synthesis in vitro.

Authors:  H W GERARDE; M JONES
Journal:  J Biol Chem       Date:  1953-04       Impact factor: 5.157

4.  Effect of dehydroascorbic acid in rabbits.

Authors:  S BANERJEE; B BELAVADY; A K MUKHERJEE
Journal:  Proc Soc Exp Biol Med       Date:  1953-05

5.  Studies on the pathway of protein synthesis in tissue culture.

Authors:  M D FRANCIS; T WINNICK
Journal:  J Biol Chem       Date:  1953-05       Impact factor: 5.157

6.  Ascorbic acid and the formation of collagen.

Authors:  W B VAN ROBERTSON; B SCHWARTZ
Journal:  J Biol Chem       Date:  1953-04       Impact factor: 5.157

7.  A modified method for determination of hydroxyproline.

Authors:  C J MARTIN; A E AXELROD
Journal:  Proc Soc Exp Biol Med       Date:  1953-07

8.  Protein synthesis and amino acid turnover in tissue culture.

Authors:  H W GERARDE; M JONES; T WINNICK
Journal:  J Biol Chem       Date:  1952-05       Impact factor: 5.157

9.  The determination of collagen and elastin in tissues.

Authors:  R E NEUMAN; M A LOGAN
Journal:  J Biol Chem       Date:  1950-10       Impact factor: 5.157

10.  [Conditions of cellular nutrition in vitro in culture without plasma base; role of micro- and macrocellular fractions].

Authors:  G BARSKI; J MAURIN; G WIELGOSZ; P LEPINE
Journal:  Ann Inst Pasteur (Paris)       Date:  1951-07
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  4 in total

1.  DEVELOPMENT OF COLLAGEN IN THE FROG EMBRYO.

Authors:  M V Edds
Journal:  Proc Natl Acad Sci U S A       Date:  1958-04       Impact factor: 11.205

2.  [Studies on explanted keloid tissue].

Authors:  E Szabó; P Ladányi; F A Kiss
Journal:  Arch Dermatol Forsch       Date:  1971

3.  Wound healing and collagen formation. I. Sequential changes in components of guinea pig skin wounds observed in the electron microscope.

Authors:  R ROSS; E P BENDITT
Journal:  J Biophys Biochem Cytol       Date:  1961-12

4.  Primary cultures of dissociated sympathetic neurons. II. Initial studies on catecholamine metabolism.

Authors:  R E Mains; P H Patterson
Journal:  J Cell Biol       Date:  1973-11       Impact factor: 10.539
  4 in total

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