Literature DB >> 1346780

Physical mapping of a 950-kb region surrounding a locus (D10S102) tightly linked to the MEN2A gene.

T Tokino1, T Imai, A Tanigami, S Takiguchi, Y Nakamura.   

Abstract

We have constructed a long-range contig of cosmid and YAC clones around D10S102, a locus that is tightly linked to the gene responsible for multiple endocrine neoplasia type 2A (MEN2A). With D10S102 as a starting point, a 360-kb cosmid contig was constructed by bidirectional genomic walking, and at least six fragments from these cosmids showed high sequence homology to other species. Five YAC clones were also isolated at the D10S102 locus, and they formed a contig covering 950 kb of genomic DNA. Furthermore, we obtained six RFLP systems from the contig, which will serve as new resources for fine-scale genetic linkage mapping of the MEN2A locus.

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Year:  1992        PMID： 1346780     DOI： 10.1016/0888-7543(92)90390-e

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  4 in total

1.  Ordering of markers in the pericentromeric region of chromosome 10.

Authors:  R M Hofstra; T Stelwagen; B Pasini; A Y van der Veen; B A Ponder; Y Nakamura; G Romeo; C H Buys
Journal:  Hum Genet       Date:  1995-07       Impact factor: 4.132

2.  Identification of Evi-3, a novel common site of retroviral integration in mouse AKXD B-cell lymphomas.

Authors:  M J Justice; H C Morse; N A Jenkins; N G Copeland
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

3.  A 1.5-megabase yeast artificial chromosome contig from human chromosome 10q11.2 connecting three genetic loci (RET, D10S94, and D10S102) closely linked to the MEN2A locus.

Authors:  T C Lairmore; S Dou; J R Howe; D Chi; K Carlson; R Veile; S K Mishra; S A Wells; H Donis-Keller
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-15       Impact factor: 11.205

4.  Germline mutations of the RET proto-oncogene in eight Japanese patients with multiple endocrine neoplasia type 2A (MEN2A).

Authors:  S Takiguchi-Shirahama; K Koyama; A Miyauchi; T Wakasugi; S Oishi; H Takami; K Hikiji; Y Nakamura
Journal:  Hum Genet       Date:  1995-02       Impact factor: 4.132
  4 in total

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