Literature DB >> 13460246

Histamine release and pain production by xanthosine and related compounds.

R MOULTON, W G SPECTOR, D A WILLOUGHBY.   

Abstract

Xanthosine (5 to 50 mug.) caused pain on intradermal injection in all human subjects tested: in about half the subjects it also gave a flare. Inosinic acid, uric acid, allantoin, alloxan and theophylline caused pain, but not a flare by intradermal injection in man. Xanthine caused both pain and flare. A number of related compounds in similar doses caused neither pain nor flare. Inosine, inosinic acid, and guanosine, but not xanthosine, were powerful histamine liberators in animals. The lowering of the cat blood pressure, depression of the activity of the guinea-pig ileum and stimulation of guinea-pig uterus by adenosine were confirmed.

Entities:  

Keywords:  HISTAMINE/physiology; NUCLEOSIDES AND NUCLEOTIDES/effects; PAIN/experimental

Mesh：

Substances：

Year:  1957        PMID： 13460246      PMCID： PMC1509694          DOI： 10.1111/j.1476-5381.1957.tb00150.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN： 0366-0826


  8 in total

1.  Erythrocyte preservation. V. Relationship between chemical changes and viability of stored blood treated with adenosine.

Authors:  B W GABRIO; D M DONOHUE; C A FINCH
Journal:  J Clin Invest       Date:  1955-10       Impact factor: 14.808

2.  A study of the metabolism of phosphorus in mammalian red cells.

Authors:  T A PRANKERD; K I ALTMAN
Journal:  Biochem J       Date:  1954-12       Impact factor: 3.857

3.  Observations on chemical excitants of cutaneous pain in man.

Authors:  D ARMSTRONG; R M L DRY; C A KEELE; J W MARKHAM
Journal:  J Physiol       Date:  1953-05-28       Impact factor: 5.182

4.  Release of histamine from skin and muscle in the cat by opium alkaloids and other histamine liberators.

Authors:  W FELDBERG; W D M PATON
Journal:  J Physiol       Date:  1951-08       Impact factor: 5.182

5.  An unidentified depressor substance in certain tissue extracts.

Authors:  U S V Euler; J H Gaddum
Journal:  J Physiol       Date:  1931-06-06       Impact factor: 5.182

6.  The role of some higher peptides in inflammation.

Authors:  W G SPECTOR
Journal:  J Pathol Bacteriol       Date:  1951-01

7.  The liberation of histamine by certain organic bases.

Authors:  F C MACINTOSH; W D M PATON
Journal:  J Physiol       Date:  1949-08       Impact factor: 5.182

8.  The release of histamine by d-tubocurarine from the isolated diaphragm of the rat.

Authors:  M ROCHA E SILVA; H O SCHILD
Journal:  J Physiol       Date:  1949-09       Impact factor: 5.182
  8 in total
  6 in total

1.  The inflammatory response.

Authors:  W G SPECTOR; D A WILLOUGHBY
Journal:  Bacteriol Rev       Date:  1963-06

2.  Professor Derek Albert Willoughby (1930-2004).

Authors:  K D Rainsford
Journal:  Inflammopharmacology       Date:  2005       Impact factor: 4.473

3.  Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. 1970.

Authors:  G Burnstock; G Campbell; D Satchell; A Smythe
Journal:  Br J Pharmacol       Date:  1997-02       Impact factor: 8.739

4.  Protection against burn, tourniquet and endotoxin shock by histamine, 5-hydroxytryptamine and 5-hydroxytryptamine derivatives.

Authors:  K Markley; E Smallman; S W Thornton
Journal:  Br J Pharmacol       Date:  1971-05       Impact factor: 8.739

5.  Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut.

Authors:  G Burnstock; G Campbell; D Satchell; A Smythe
Journal:  Br J Pharmacol       Date:  1970-12       Impact factor: 8.739

6.  Organic and Peptidyl Constituents of Snake Venoms: The Picture Is Vastly More Complex Than We Imagined.

Authors:  Alejandro Villar-Briones; Steven D Aird
Journal:  Toxins (Basel)       Date:  2018-09-26       Impact factor: 4.546
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.