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Literature DB >> 13460235

Effects of choline 2:6-xylyl ether bromide upon the suprarenal medulla of the rat.

Abstract

The administration of choline 2:6-xylyl ether bromide (TM 10) daily to rats for two weeks depletes the suprarenals of about one-half their normal content of adrenaline and noradrenaline. This depletion has been demonstrated histologically and by colorimetric and biological estimation of the amines present in extracts of the glands. Treatment with TM 10 causes similar histological signs of depletion in autografts of adrenal chromaffin tissue in the rat iris. Restoration of catechol amines in rat suprarenals, previously depleted by TM 10, occurs slowly and appears to be complete 14 days after withdrawing the drug. These results, considered in conjunction with the estimated rate of turnover of catechol amines in the rat suprarenal, lend support to the view that TM 10 may interfere with the biosynthesis of these amines.

Entities: Chemical Species

Keywords: ADRENAL MEDULLA/effect of drugs on; CHOLINE/related compounds

Mesh：

Substances：

Year: 1957 PMID： 13460235 PMCID： PMC1509690 DOI： 10.1111/j.1476-5381.1957.tb00139.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

9 in total

6 in total

4. Extra-vesicular binding of noradrenaline and guanethidine in the adrenergic neurones of the rat heart: a proposed site of action of adrenergic neurone blocking agents.

Authors: A Giachetti; R A Hollenbeck
Journal: Br J Pharmacol Date: 1976-12 Impact factor: 8.739

5. Effects of drugs which depress the peripheral nervous system on the reticular activating system of the cat.

Authors: K A EXLEY; M C FLEMING; A D ESPELIEN
Journal: Br J Pharmacol Chemother Date: 1958-12

6. The antagonism of cocaine to the action of choline 2,6-xylyl ether bromide at sympathetic nerve endings.

Authors: P A NASMYTH; W H ANDREWS
Journal: Br J Pharmacol Chemother Date: 1959-12

6 in total

Effects of choline 2:6-xylyl ether bromide upon the suprarenal medulla of the rat.

1. Some pharmacological actions of choline 2:6-xylyl ether bromide.

2. Choline phenyl ethers as inhibitors of amine oxidase.

3. Formation of catechol amines during splanchnic stimulation of the adrenal gland of the cat.

4. Choline 2 : 6-xylyl ether bromide; an active quaternary local anaesthetic.

5. Evidence of adrenaline and noradrenaline in separate adrenal medullary cells.

6. Rate of turnover of epinephrine in the adrenal medulla.

7. On the morphology and adrenaline-nor-adrenaline content of chromaffin tissue.

8. Some actions of substituted choline phenyl ethers, particularly of choline 2:6-xylyl ether.

9. The blocking action of choline 2:6-xylyl ether bromide on adrenergic nerves.

1. A possible role of an inhibitory system in virus-infected sympathetic ganglia of the rat.

2. The actions of bretylium: adrenergic neurone blocking and other effects. 1959.

3. The release of catechol amines by choline 2,6-XYLYL ether, bretylium and guanethidine.

4. Extra-vesicular binding of noradrenaline and guanethidine in the adrenergic neurones of the rat heart: a proposed site of action of adrenergic neurone blocking agents.

5. Effects of drugs which depress the peripheral nervous system on the reticular activating system of the cat.

6. The antagonism of cocaine to the action of choline 2,6-xylyl ether bromide at sympathetic nerve endings.