The effects of fluoride feeding on the organic matrix of bones and teeth of pigs as observed by autoradiography after in vitro uptake of Ca45 and S35.

Demineralized sections of fluorinated bones and teeth have been studied by autoradiography following in vitro uptake of Ca(45) or S(35)O(4). The portions of tissue which do not become mineralized (cartilage, prebone, predentine, and precementum) show an increased Ca(45) uptake apparently related to an increase in chondroitin sulfate content in fluorosis. The tissues from the fluoride-fed animals show an increase of in vitro uptake of sulfur in the tissues which become mineralized (bone, dentine, cementum).