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Literature DB >> 13446378

Anticonvulsant compounds and 5-hydroxytryptamine in rat brain.

D D BONNYCASTLE, N J GIARMAN, M K PAASONEN.

Abstract

In rats, a series of anticonvulsant compounds have been shown to cause a significant elevation of brain 5-hydroxytryptamine (5-HT) levels in comparison with control values. This increase in 5-HT only occurred in brain tissue and was not observed in spleen, upper small intestine or blood. Elevation of brain levels of 5-HT by iproniazid (Marsilid) or 5-hydroxytryptophan failed to give protection against the convulsant or lethal action of lept zol (75 mg./kg.).

Entities: Chemical Species

Keywords: ANTICONVULSANTS/effects; BRAIN/metabolism; SEROTONIN/metabolism

Mesh：

Substances：

Year: 1957 PMID： 13446378 PMCID： PMC1509665 DOI： 10.1111/j.1476-5381.1957.tb00125.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

5 in total

1. The use of some molluscan hearts for the estimation of 5-hydroxytryptamine.

Authors: J H GADDUM; M K PAASONEN
Journal: Br J Pharmacol Chemother Date: 1955-12

2. Diphenylhydantoin and brain-levels and 5-hydroxytryptamine.

Authors: D D BONNYCASTLE; N J GIARMAN; M K PAASONEN
Journal: Nature Date: 1956-11-03 Impact factor: 49.962

3. Use of meprobamate (Miltown) in convulsive and related disorders.

Authors: M A PERLSTEIN
Journal: J Am Med Assoc Date: 1956-07-14

4. The distribution of substance P and 5-hydroxytryptamine in the central nervous system of the dog.

Authors: A H AMIN; T B CRAWFORD; J H GADDUM
Journal: J Physiol Date: 1954-12-10 Impact factor: 5.182

5. Serotonin content of some mammalian tissues and urine and a method for its determination.

Authors: B M TWAROG; I H PAGE
Journal: Am J Physiol Date: 1953-10

5 in total

34 in total

1. EFFECTS OF GAMMA-AMINO-BETA-HYDROXYBUTYRIC ACID ON CEREBRAL AMINES.

Authors: M MACCARI; G C MAGGI
Journal: Br J Pharmacol Chemother Date: 1965-04

2. An anticonvulsant effect of monoamine oxidase inhibitors.

Authors: D J PROCKOP; P A SHORE; B B BRODIE
Journal: Experientia Date: 1959-04-15

3. Electroshock, brain serotonin, and barbiturate narcosis.

Authors: S GARATTINI; R KATO; L LAMESTA; L VALZELLI
Journal: Experientia Date: 1960-04-15

4. The effect of pentobarbital on brain 5-HT metabolism in mice.

Authors: K Kuschinsky; G Seidel; E Reetz; C Meyer-Burgdorf
Journal: Experientia Date: 1973

5. Some behavioural and anticonvulsant actions in mice of ethanolamine O-sulphate, an inhibitor of 4-aminobutyrate aminotransferase.

Authors: M G Baxter; L J Fowler; A A Miller; J M Walker
Journal: Br J Pharmacol Date: 1973-03 Impact factor: 8.739

6. Amines and abnormal mood.

Authors: W G Dewhurst
Journal: Proc R Soc Med Date: 1969-11

Review 7. Drugs and folate metabolism.

Authors: D G Lambie; R H Johnson
Journal: Drugs Date: 1985-08 Impact factor: 9.546