| Literature DB >> 1343870 |
J Henderson1, C Yiannikas, J S Graham.
Abstract
There is both experimental and clinical evidence to suggest a role for 5-hydroxytryptamine (5-HT) in Parkinson's disease. The effect of ritanserin, a highly selective 5-HT2 receptor antagonist, on Parkinsonian symptomatology was investigated in 10 patients in a single-blind placebo-controlled study. Akinesia and gait improved significantly in a dose-dependent manner in 5 and 7 patients respectively. However there was no significant improvement in tremor. The effects of ritanserin on akinesia and gait are consistent with a role for 5-HT in Parkinson's disease.Entities:
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Year: 1992 PMID： 1343870
Source DB: PubMed Journal: Clin Exp Neurol ISSN： 0196-6383