The effect of early hypoxy upon the development of rats and mice. 1. Preimplantation effects.

The effect of temporary hypoxy obtained by uterine vascular clamping during the preimplantation developmental period, was controlled on rats and mice (on the last day of preimplantation development). The following main effects were detected: retarded preimplantation development in rats; increased number of pathologically modified embryos and retarded oviduct-uterus migration in both species. The changes of the uterine wall due to vascular clamping disappear two days after the experimental intervention. The existence of an experimental hypoxic blastopathy is attested (at least its early, preimplantation aspect).