Literature DB >> 1342066

Structural alterations of the ribosomal RNA genes in leukemic cells.

I A Smirnova1.   

Abstract

Cloned 6.7 kb EcoR1 fragment of mice rDNA was used as a hybridization probe for rDNA structure analysis in mice, rat and calf haemopoietic tumor and normal cells. EcoR1, BglII and Pst1 restriction fragment length polymorphism (RFLP) was found in neoplastic rDNA and was not revealed in normal ones. The rRNA gene rearrangements were observed not only in spacer region but in coding sequences of the genes. Leukemic cells reveal also rDNA amplification. A role of genetic rearrangements of rDNA for mechanisms of carcinogenesis is suggested.

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Year:  1992        PMID： 1342066     DOI： 10.1007/bf02987758

Source DB:  PubMed          Journal:  Med Oncol Tumor Pharmacother        ISSN： 0736-0118


  16 in total

1.  The evolution of eukaryotic ribosomal DNA.

Authors:  S A Gerbi
Journal:  Biosystems       Date:  1986       Impact factor: 1.973

2.  A single base change in the Shine-Dalgarno region of 16S rRNA of Escherichia coli affects translation of many proteins.

Authors:  W F Jacob; M Santer; A E Dahlberg
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205

3.  Secondary activation of c-abl may be related to translocation to the nucleolar organizer region in an in vitro cultured rat leukemia cell line (K3D).

Authors:  R Takahashi; K Mihara; S Maeda; T Yamaguchi; H L Chen; N Aoyama; S Murao; M Hatanaka; T Sugiyama
Journal:  Proc Natl Acad Sci U S A       Date:  1986-02       Impact factor: 11.205

4.  Structural analysis of the human U3 ribonucleoprotein particle reveal a conserved sequence available for base pairing with pre-rRNA.

Authors:  K A Parker; J A Steitz
Journal:  Mol Cell Biol       Date:  1987-08       Impact factor: 4.272

5.  In vitro synthesis of 16S ribosomal RNA containing single base changes and assembly into a functional 30S ribosome.

Authors:  W Krzyzosiak; R Denman; K Nurse; W Hellmann; M Boublik; C W Gehrke; P F Agris; J Ofengand
Journal:  Biochemistry       Date:  1987-04-21       Impact factor: 3.162

6.  Characterization of rat ribosomal DNA. The highly repetitive sequences that flank the ribosomal RNA transcription unit are homologous and contain RNA polymerase III transcription initiation sites.

Authors:  D L Mroczka; B Cassidy; H Busch; L I Rothblum
Journal:  J Mol Biol       Date:  1984-03-25       Impact factor: 5.469

7.  Changes in nucleolar and ribosomal RNA of the frog kidney after malignant transformation by the Lucke tumor herpesvirus.

Authors:  K S Tweedell; J H Malin
Journal:  Exp Cell Biol       Date:  1984

8.  Organization of ribosomal RNA gene repeats of the mouse.

Authors:  R Kominami; Y Urano; Y Mishima; M Muramatsu
Journal:  Nucleic Acids Res       Date:  1981-07-24       Impact factor: 16.971

9.  Quantitative estimation of nucleolar cistrons (rDNA) in proliferating normal and tumor cells.

Authors:  T Sugiyama; Y Kano; S Maeda; S Murao; Y Horita
Journal:  Gan       Date:  1980-06

10.  Level of ribosomal RNA required for stimulation from quiescence increases during cellular aging in vitro of mammalian fibroblasts.

Authors:  G Adam; A Simm; F Braun
Journal:  Exp Cell Res       Date:  1987-04       Impact factor: 3.905
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