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Literature DB >> 13416530

Adaptation of Bacillus megatherium to terramycin (oxytetracycline).

Abstract

B. megatherium cultures contain a few cells per hundred million which are able to grow in the presence of terramycin. Growth of the other cells is inhibited by the antibiotic with the result that the resistant cells overgrow the culture. The resistant cells are present in the culture, without contact with terramycin, and are able to grow in the presence of terramycin, without further modification. The resistant cells are mutants of sensitive cells.

Entities: Chemical

Keywords: BACILLUS MEGATERIUM/effect of drugs on; OXYTETRACYCLINE/effects

Mesh：

Substances：
Oxytetracycline

Year: 1957 PMID： 13416530 PMCID： PMC2147641 DOI： 10.1085/jgp.40.4.547

Source DB: PubMed Journal: J Gen Physiol ISSN： 0022-1295 Impact factor: 4.086

15 in total

1. Bacterial resistance.

Authors: V BRYSON; M DEMEREC
Journal: Am J Med Date: 1955-05 Impact factor: 4.965

2. Antibiotic combinations and resistance to antibiotics; development of resistance during repeated subcultures of Staphylococci and certain Streptococci on media containing penicillin, streptomycin, erythromycin, terramycin, and chloramphenicol used singly and in pairs.

Authors: S S WRIGHT; E M PURCELL; C WILCOX; M K BRODERICK; M FINLAND
Journal: J Lab Clin Med Date: 1953-12

8. Growth and phage production of B. megatherium. I. Growth of cells after infection with C phage. II. Rate of growth, phage yield, and RNA content of cells. III. Effect of various substances on growth rate and phage production.

Authors: J H NORTHROP
Journal: J Gen Physiol Date: 1953-03 Impact factor: 4.086

9. Inactivation and reactivation of B. megatherium phage.

Authors: J H NORTHROP
Journal: J Gen Physiol Date: 1955-11-20 Impact factor: 4.086

10. Appearance of new phage types and new lysogenic strains after adaptation of lysogenic B. megatherium to ammonium sulfate culture medium.

Authors: J H NORTHROP; J S MURPHY
Journal: J Gen Physiol Date: 1956-03-20 Impact factor: 4.086

5 in total

1. CONCERNING THE ORIGIN OF BACTERIAL VIRUSES.

Authors: J H Northrop
Journal: Proc Natl Acad Sci U S A Date: 1958-03 Impact factor: 11.205

2. Mutagens and infectious nucleic acids.

Authors: J H NORTHROP; F CAVALLERO
Journal: Proc Natl Acad Sci U S A Date: 1961-10-15 Impact factor: 11.205

3. Apparatus for the Maintenance of Bacterial Cultures in the Steady State : II. Improved turbidity control and culture cell.

Authors: J H Northrop
Journal: J Gen Physiol Date: 1960-01-01 Impact factor: 4.086

4. Studies on the origin of bacterial viruses. I-IV.

Authors: J H NORTHROP
Journal: J Gen Physiol Date: 1958-09-20 Impact factor: 4.086

5. Studies of the Origin of Bacterial Viruses : VII. The effect of various mutagens (urethane, ethyl urethane, hydrogen peroxide, desoxycholate, maleic hydrazide, butadiene dioxide, triethylene melamine, versene, and acriflavine) on the proportion of virus-producing and streptomycin-resistant cells in cultures of B. megatherium 20delta.

Authors: J H Northrop
Journal: J Gen Physiol Date: 1963-05-01 Impact factor: 4.086

5 in total

Adaptation of Bacillus megatherium to terramycin (oxytetracycline).

1. Bacterial resistance.

2. Antibiotic combinations and resistance to antibiotics; development of resistance during repeated subcultures of Staphylococci and certain Streptococci on media containing penicillin, streptomycin, erythromycin, terramycin, and chloramphenicol used singly and in pairs.

3. Transduction of flagellar characters in Salmonella.

4. Sero-typic recombination in Salmonella.

5. Metabolite reversal of antibiotic inhibition, especially reversal of aureomycin inhibition by riboflavin.

6. [Lysogenic induction in Micrococcus pyogenes aureus].

7. Patterns of resistance to antimicrobial agents.