Experiments with the trypanocidal compound 528 in West Africa.

Studies have been made on the use of the chloride salt of "528" against cattle trypanosomiasis in Nigeria. Toxic effects, terminating in death, were produced in cattle receiving the drug at 5 mg./kg. and above. The maximum permissible dose for field use in Nigeria was found to be 2 mg./kg. The drug had an appreciable curative action against a syringe-transmitted strain of T. congolense, but had no curative effect against two strains of T. vivax. It is concluded that "528" would be of very limited value in the treatment of cattle in West Africa, where T. vivax is the more important cause of cattle trypanosomiasis.