Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Some aspects of the pharmacology of an homologous series of choline esters of fatty acids.

Literature DB >> 13413148

Some aspects of the pharmacology of an homologous series of choline esters of fatty acids.

Abstract

The pharmacological effects of a series of fatty acid-choline esters have been studied on the isolated rabbit heart, the isolated guinea-pig ileum and the rat stomach. The effect changed with increasing chain length, and three different types of response were observed. The shortchain compounds produced depression of the isolated rabbit heart and spasm of the isolated guinea-pig ileum. Only one, butyrylcholine, had an erratic stimulating effect on hydrochloric acid secretion by the partially vagotomized rat stomach. Medium-chain compounds had a stimulating effect on the isolated rabbit heart, a mixed spasmogenic and relaxant effect on the isolated guinea-pig ileum, and no effect on the rat stomach. Long-chain compounds blocked the effect of acetylcholine on the isolated rabbit heart and the isolated guinea-pig ileum; they also depressed spontaneous hydrochloric acid secretion by the rat stomach. The nature of these three types of response is discussed.

Entities: Chemical Disease Species

Keywords: CHOLINE/related compounds; FATTY ACIDS/effects; HEART/effect of drugs on; ILEUM/effect of drugs on; STOMACH/effect of drugs on

Mesh：

Substances：

Year: 1957 PMID： 13413148 PMCID： PMC1509636 DOI： 10.1111/j.1476-5381.1957.tb01358.x

Source DB: PubMed Journal: Br J Pharmacol Chemother ISSN： 0366-0826

11 in total

1. The use of a selective acetylcholinesterase inhibitor in the estimation of pseudocholinesterase activity in rat brain.

Authors: B J BAYLISS; A TODRICK
Journal: Biochem J Date: 1956-01 Impact factor: 3.857

2. Improved automatic apparatus for pharmacological assays on isolated preparations.

Authors: A BOURA; J L MONGAR; H O SCHILD
Journal: Br J Pharmacol Chemother Date: 1954-03

3. Reactions of nerve-free and chronically denervated plain muscle to drugs.

Authors: D H EVANS; H O SCHILD
Journal: J Physiol Date: 1953 Impact factor: 5.182

4. Nicotine-like actions in auricles and blood vessels after denervation.

Authors: K H GINZEL; S R KOTTEGODA
Journal: Br J Pharmacol Chemother Date: 1953-09

5. Stimulation of isolated rabbit auricles by substances which is stimulate ganglia.

Authors: S R KOTTEGODA
Journal: Br J Pharmacol Chemother Date: 1953-03

6. The excitant action of acetylcholine and other substances on cutaneous sensory pathways and its prevention by hexamethonium and D-tubocurarine.

Authors: W W DOUGLAS; J A B GRAY
Journal: J Physiol Date: 1953-01 Impact factor: 5.182

7. The role of acetylcholine in synaptic transmission at parasympathetic ganglia.

Authors: W L M PERRY; J TALESNIK
Journal: J Physiol Date: 1953-03 Impact factor: 5.182

8. Unmasking, after cholinergic paralysis by botulinum toxin, of a reversed action of nicotine on the mammalian intestine, revealing the probable presence of local inhibitory ganglion cells in the enteric plexuses.

Authors: N AMBACHE
Journal: Br J Pharmacol Chemother Date: 1951-03

Some aspects of the pharmacology of an homologous series of choline esters of fatty acids.

1. The use of a selective acetylcholinesterase inhibitor in the estimation of pseudocholinesterase activity in rat brain.

2. Improved automatic apparatus for pharmacological assays on isolated preparations.

3. Reactions of nerve-free and chronically denervated plain muscle to drugs.

4. Nicotine-like actions in auricles and blood vessels after denervation.

5. Stimulation of isolated rabbit auricles by substances which is stimulate ganglia.

6. The excitant action of acetylcholine and other substances on cutaneous sensory pathways and its prevention by hexamethonium and D-tubocurarine.

7. The role of acetylcholine in synaptic transmission at parasympathetic ganglia.

8. Unmasking, after cholinergic paralysis by botulinum toxin, of a reversed action of nicotine on the mammalian intestine, revealing the probable presence of local inhibitory ganglion cells in the enteric plexuses.

9. Effects of ganglion-blocking substances on the small intestine.

10. The pharmacology of benzoylcholine.

1. The role of ionic interaction at the muscarinic receptor.

2. Metabolomic response to collegiate football participation: Pre- and Post-season analysis.

3. Comprehensive Circulatory Metabolomics in ME/CFS Reveals Disrupted Metabolism of Acyl Lipids and Steroids.