Literature DB >> 13413146

The effect of eserine and neostigmine on the blood pressure of conscious rats.

M MEDAKOVIC, V VARAGIC.   

Abstract

Small amounts of eserine salicylate (10 to 20 mug.) regularly caused a rise of blood pressure in non-anaesthetized rats. Neostigmine methylsulphate in doses from 1 to 10 mug./animal usually caused a fall of blood pressure, or no change was observed; only in a few experiments was a rise of blood pressure noted. The pressor effect of eserine was abolished by atropine and reduced or abolished by yohimbine and phentolamine. Adrenalectomy did not change the response to eserine. The present experiments do not contradict earlier statements that the pressor effect of eserine was due to the discharge of impulses from a centre or centres in the central nervous system.

Entities:  

Keywords:  BLOOD PRESSURE/effect of drugs on; NEOSTIGMINE/effects; PHYSOSTIGMINE/effects

Mesh:

Substances:

Year:  1957        PMID: 13413146      PMCID: PMC1509647          DOI: 10.1111/j.1476-5381.1957.tb01356.x

Source DB:  PubMed          Journal:  Br J Pharmacol Chemother        ISSN: 0366-0826


  6 in total

1.  The effect of anti-cholinesterase agents on the rat's blood pressure.

Authors:  P DIRNHUBER; H CULLUMBINE
Journal:  Br J Pharmacol Chemother       Date:  1955-03

2.  [Effects of physostigmine, tetraethylpyrophosphate, and neostigmine on the blood pressure and pressor reflexes of the carotid sinus in rats].

Authors:  O HORNYKIEWICZ; W KOBINGER
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1956

3.  Pharmacological investigations on a central synapse operated by acetylcholine.

Authors:  J C ECCLES; D M ECCLES; P FATT
Journal:  J Physiol       Date:  1956-01-27       Impact factor: 5.182

4.  Indirect measurement of the blood pressure in the rat.

Authors:  E G VAN PROOSDIJ-HARTZEMA
Journal:  Acta Physiol Pharmacol Neerl       Date:  1954

5.  Cholinergic and inhibitory synapses in a pathway from motor-axon collaterals to motoneurones.

Authors:  J C ECCLES; P FATT; K KOKETSU
Journal:  J Physiol       Date:  1954-12-10       Impact factor: 5.182

6.  Action of atropine on sympathetic ganglia.

Authors:  R L CAHEN; K M TVEDE
Journal:  Arch Int Pharmacodyn Ther       Date:  1953-06
  6 in total
  9 in total

1.  DIFFERENCE BETWEEN THE BLOOD PRESSURE RESPONSES TO INTRAJUGULAR AND INTRACAROTID INJECTIONS PHYSOSTIGMINE, AND THE SYNDROME OF CONTRALATERAL TORSION IN THE RAT.

Authors:  M KRSTIC; V VARAGIC
Journal:  Br J Pharmacol Chemother       Date:  1965-02

2.  ANTAGONISM OF THE BLOCKING ACTION OF BRETYLIUM AND GUANETHIDINE ON THE PRESSOR EFFECT OF PHYSOSTIGMINE IN THE RAT.

Authors:  S D GOKHALE; O D GULATI; N Y JOSHI
Journal:  Br J Pharmacol Chemother       Date:  1965-06

3.  Reversal of haemorrhagic shock in rats by cholinomimetic drugs.

Authors:  S Guarini; S Tagliavini; W Ferrari; A Bertolini
Journal:  Br J Pharmacol       Date:  1989-09       Impact factor: 8.739

4.  [Modification of the eserine pressor effect by propranolol].

Authors:  H Brunner; P Hedwall; L Maître; M Meier
Journal:  Naunyn Schmiedebergs Arch Pharmakol Exp Pathol       Date:  1966

5.  Role of neuronal and vascular Ca(2+)-channels in the ACTH-induced reversal of haemorrhagic shock.

Authors:  S Guarini; C Bazzani; A Bertolini
Journal:  Br J Pharmacol       Date:  1993-07       Impact factor: 8.739

6.  Increased pressor responses to physostigmine in spontaneously hypertensive rats.

Authors:  T Kubo; M Tatsumi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-01       Impact factor: 3.000

7.  Nicotine reverses hemorrhagic shock in rats.

Authors:  S Guarini; S Tagliavini; C Bazzani; A Bertolini; W Ferrari
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-04       Impact factor: 3.000

8.  EFFECT OF SOME BLOCKING DRUGS ON THE PRESSOR RESPONSE TO PHYSOSTIGMINE IN THE RAT.

Authors:  S D GOKHALE; O D GULATI; N Y JOSHI
Journal:  Br J Pharmacol Chemother       Date:  1963-10

9.  The effects of paraoxon on blood pressure in the anaesthetized and in the conscious rat.

Authors:  J H De Neef; K M Jordaan; A J Porsius
Journal:  Br J Pharmacol       Date:  1982-10       Impact factor: 8.739

  9 in total

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