Literature DB >> 134128

The effect of membrane stabilizing agents on induction of the immune response. I. Effect of lymphocyte activation in mixed lymphocyte reactions.

J D Waterfield, L Hammarström, E Smith.   

Abstract

The effect of three membrane-stabilizing agents, chlorpromazine, imipramine, and lidocain, on in vitro activation of cellular responses was studied using the one-way MLR. Cellular activation was found to be depressed by these drugs. However, the degree of suppression paralleled the decline of viable cells in the cultures. It is concluded that drug-induced inhibition of MLR was due solely to the toxicity of the compounds.

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Year:  1976        PMID： 134128      PMCID： PMC2190378          DOI： 10.1084/jem.144.2.562

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  5 in total

1.  Differential effects of chlorpromazine on the in vitro generation and effector function of cytotoxic lymphocytes.

Authors:  R M Ferguson; J R Schmidtke; R L Simmons
Journal:  J Exp Med       Date:  1976-01-01       Impact factor: 14.307

2.  The involvement of LD- and SD-region differences in MLC and CML: a three-cell experiment.

Authors:  D J Schendel; B J Alter; F H Bach
Journal:  Transplant Proc       Date:  1973-12       Impact factor: 1.066

3.  Cell mediated immunity: separation of cells involved in recognitive and destructive phases.

Authors:  F H Bach; M Segall; K S Zier; P M Sondel; B J Alter; M L Bach
Journal:  Science       Date:  1973-04-27       Impact factor: 47.728

4.  Mixed lymphocyte cultures produce effector cells: model in vitro for allograft rejection.

Authors:  P Häyry; V Defendi
Journal:  Science       Date:  1970-04-03       Impact factor: 47.728

5.  Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.

Authors:  H Cantor; E A Boyse
Journal:  J Exp Med       Date:  1975-06-01       Impact factor: 14.307
  5 in total
  2 in total

1.  Enhanced recovery of murine alveolar macrophages: morphological and functional characteristics following intravenous injection of heat-killed Mycobacterium bovis BCG.

Authors:  I N Mbawuike; J E Luhr; H B Herscowitz
Journal:  Infect Immun       Date:  1986-02       Impact factor: 3.441

2.  The immunosuppressive activities of newly synthesized azaphenothiazines in human and mouse models.

Authors:  Michał Zimecki; Jolanta Artym; Maja Kocieba; Krystian Pluta; Beata Morak-Młodawska; Małgorzata Jeleń
Journal:  Cell Mol Biol Lett       Date:  2009-06-25       Impact factor: 5.787
  2 in total

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