Literature DB >> 1340597

[Evaluation of the therapeutic activity of fluconazole in acute experimental infection caused by Trypanosoma cruzi].

R Campos1, V Amato Neto, A A Moreira, H B de Souza, M Okumura, P L Pinto, L M Braz, M F Silva, L Matsubara.   

Abstract

On hand of information that fluconazole can inhibit Trypanosoma cruzi, infection, an experimental investigation in acutely infected mice treated with 200 mg/kg daily of this drug during one month was carried out. Parasitemia patency, blood culture, sub-inoculation and histologic examination were the parameters used to evaluate the potential therapeutic activity of the drug. The results did not confirm the hypothesis, but it would be desirable to conduct new trials with this and other imidazole compounds.

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Year:  1992        PMID: 1340597

Source DB:  PubMed          Journal:  Rev Hosp Clin Fac Med Sao Paulo        ISSN: 0041-8781


  4 in total

Review 1.  Design or screening of drugs for the treatment of Chagas disease: what shows the most promise?

Authors:  Galina I Lepesheva
Journal:  Expert Opin Drug Discov       Date:  2013-09-30       Impact factor: 6.098

2.  Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase.

Authors:  F S Buckner; C L Verlinde; A C La Flamme; W C Van Voorhis
Journal:  Antimicrob Agents Chemother       Date:  1996-11       Impact factor: 5.191

Review 3.  CYP51 as drug targets for fungi and protozoan parasites: past, present and future.

Authors:  Galina I Lepesheva; Laura Friggeri; Michael R Waterman
Journal:  Parasitology       Date:  2018-04-12       Impact factor: 3.234

4.  Identification of three classes of heteroaromatic compounds with activity against intracellular Trypanosoma cruzi by chemical library screening.

Authors:  Esther Bettiol; Marie Samanovic; Andrew S Murkin; Jayne Raper; Frederick Buckner; Ana Rodriguez
Journal:  PLoS Negl Trop Dis       Date:  2009-02-24
  4 in total

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