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Literature DB >> 1339844

Adverse effects of gonadotrophin treatment on pre- and postimplantation development in mice.

Abstract

The effect of gonadotrophins on pre- and postimplantation development in mice was investigated by superovulating C57BL/6J/Bom females with pregnant mares' serum gonadotrophin (PMSG) and human chorionic gonadotrophin (hCG) or by inducing ovulation with hCG. In both hormone treated groups, the proportion of abnormal preimplantation embryos increased compared with naturally ovulating animals. Postimplantation mortality increased and the mean number of live fetuses per pregnant mouse decreased in superovulated and hCG-treated mice compared with controls. Embryonic growth was highly retarded. Mean weight of live fetuses in superovulated and hCG-treated mice was reduced and skeletal examination revealed developmental retardation. In conclusion, superovulation as well as induction of ovulation adversely affected embryonic and fetal development.

Entities: Disease Gene Species

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Year: 1992 PMID： 1339844 DOI： 10.1530/jrf.0.0960649

Source DB: PubMed Journal: J Reprod Fertil ISSN： 0022-4251

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Cited

19 in total

1. Immunization against endogenous inhibin increases normal oocyte/embryo production in adult mice.

Authors: Mohamed S Medan; Haibin Wang; Gen Watanabe; Akira K Suzuki; Kazuyoshi Taya
Journal: Endocrine Date: 2004-07 Impact factor: 3.633

Review 2. The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment.

Authors: Mohamed F M Mitwally; Robert F Casper; Michael P Diamond
Journal: Reprod Biol Endocrinol Date: 2005-10-04 Impact factor: 5.211

3. Less is more: increased gonadotropin use for ovarian stimulation adversely influences clinical pregnancy and live birth after in vitro fertilization.

Authors: Lubna Pal; Sangita Jindal; Barry R Witt; Nanette Santoro
Journal: Fertil Steril Date: 2008-04-28 Impact factor: 7.329

4. Supraphysiologic estradiol is an independent predictor of low birth weight in full-term singletons born after fresh embryo transfer.

Authors: N Pereira; R T Elias; P J Christos; A C Petrini; K Hancock; J P Lekovich; Z Rosenwaks
Journal: Hum Reprod Date: 2017-07-01 Impact factor: 6.918

Adverse effects of gonadotrophin treatment on pre- and postimplantation development in mice.

1. Immunization against endogenous inhibin increases normal oocyte/embryo production in adult mice.

Review 2. The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment.

3. Less is more: increased gonadotropin use for ovarian stimulation adversely influences clinical pregnancy and live birth after in vitro fertilization.

4. Supraphysiologic estradiol is an independent predictor of low birth weight in full-term singletons born after fresh embryo transfer.

5. Dynamic Expression of Interleukin-33 and ST2 in the Mouse Reproductive Tract Is Influenced by Superovulation.

6. Premature ovarian aging in mice deficient for Gpr3.

7. Olfactomedin 1 Deficiency Leads to Defective Olfaction and Impaired Female Fertility.

Review 8. Female infertility: which role for obesity?

9. Treatment with gonadotropins impaired implantation and fetal development in mice.

10. Nicotine-induced cessation of embryonic development is reversed by γ-tocotrienol in mice.