Literature DB >> 1339386

Human choline acetyltransferase (CHAT): partial gene sequence and potential control regions.

J L Toussaint1, V Geoffroy, M Schmitt, A Werner, J M Garnier, P Simoni, J Kempf.   

Abstract

Choline acetyltransferase (CHAT) (EC 2.3.1.6) is the biosynthetic enzyme for the neurotransmitter acetylcholine in the central and peripheral nervous systems. In this study, a human CHAT genomic clone has been isolated and partially sequenced at its 5' end. This fragment contains the first four exons with an ACG initiator codon and potential control regions including TATA, CAAT, GC boxes, and several transcription control sequences. A comparison of the primary structure of CHAT among pig, rat, mouse, and Drosophila is presented.

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Year:  1992        PMID： 1339386     DOI： 10.1016/0888-7543(92)90395-9

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  3 in total

1.  Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease.

Authors:  Denise Harold; Timothy Peirce; Valentina Moskvina; Amanda Myers; Susan Jones; Paul Hollingworth; Pamela Moore; Simon Lovestone; John Powell; Catherine Foy; Nicola Archer; Sarah Walter; Amanda Edmonson; Stephen McIlroy; David Craig; Peter A Passmore; Alison Goate; John Hardy; Michael O'Donovan; Julie Williams; Malcolm Liddell; Michael J Owen; Lesley Jones
Journal:  Hum Genet       Date:  2003-05-21       Impact factor: 4.132

2.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1992-06-11       Impact factor: 16.971

3.  Choline acetyltransferase mutations cause myasthenic syndrome associated with episodic apnea in humans.

Authors:  K Ohno; A Tsujino; J M Brengman; C M Harper; Z Bajzer; B Udd; R Beyring; S Robb; F J Kirkham; A G Engel
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-13       Impact factor: 11.205
  3 in total

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