Literature DB >> 1339376

Cloning and analysis of a Candida maltosa gene which confers resistance to formaldehyde in Saccharomyces cerevisiae.

K Sasnauskas1, R Jomantiene, A Januska, E Lebediene, J Lebedys, A Janulaitis.   

Abstract

A gene (FDH1) of Candida maltosa which confers resistance to formaldehyde in Saccharomyces cerevisiae was cloned and its nucleotide sequence determined. The gene has a single intron which possesses the highly conserved splicing signals found in S. cerevisiae introns. We demonstrated that processing of the pre-mRNA of the cloned gene occurred identically in both S. cerevisiae and C. maltosa. The predicted amino acid sequence from the cloned gene showed 65.5% identity to human alcohol dehydrogenase (ADH) class III and 23.9% identity to S. cerevisiae ADH1. The most probable mechanism of resistance to formaldehyde is thought to be the glutathione-dependent oxidation of formaldehyde which is characteristic for ADH class III. The cloned FDH1 gene was successfully employed as a dominant selectable marker in the transformation of S. cerevisiae.

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Year:  1992        PMID： 1339376     DOI： 10.1016/0378-1119(92)90052-q

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  14 in total

1.  Pea formaldehyde-active class III alcohol dehydrogenase: common derivation of the plant and animal forms but not of the corresponding ethanol-active forms (classes I and P).

Authors:  J Shafqat; M El-Ahmad; O Danielsson; M C Martínez; B Persson; X Parés; H Jornvall
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-28       Impact factor: 11.205

2.  Cloning of the Arabidopsis and rice formaldehyde dehydrogenase genes: implications for the origin of plant ADH enzymes.

Authors:  R Dolferus; J C Osterman; W J Peacock; E S Dennis
Journal:  Genetics       Date:  1997-07       Impact factor: 4.562

3.  Maize glutathione-dependent formaldehyde dehydrogenase cDNA: a novel plant gene of detoxification.

Authors:  J Fliegmann; H Sandermann
Journal:  Plant Mol Biol       Date:  1997-08       Impact factor: 4.076

4.  Caenorhabditis elegans contains genes encoding two new members of the Zn-containing alcohol dehydrogenase family.

Authors:  J D Glasner; T D Kocher; J J Collins
Journal:  J Mol Evol       Date:  1995-07       Impact factor: 2.395

5.  Origin of the human alcohol dehydrogenase system: implications from the structure and properties of the octopus protein.

Authors:  R Kaiser; M R Fernández; X Parés; H Jörnvall
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-01       Impact factor: 11.205

6.  Fundamental molecular differences between alcohol dehydrogenase classes.

Authors:  O Danielsson; S Atrian; T Luque; L Hjelmqvist; R Gonzàlez-Duarte; H Jörnvall
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205

7.  Chromosome polymorphisms close to the cm-ADE1 locus of candida maltosa.

Authors:  D Becher; S Schulze; A Kasüske; R Stoll; H Wedler; S G Oliver
Journal:  Mol Gen Genet       Date:  1995-06-10

8.  Characterization of a glutathione-dependent formaldehyde dehydrogenase from Rhodobacter sphaeroides.

Authors:  R D Barber; M A Rott; T J Donohue
Journal:  J Bacteriol       Date:  1996-03       Impact factor: 3.490

9.  Genome-wide identification of alcohol dehydrogenase (ADH) gene family under waterlogging stress in wheat (Triticum aestivum).

Authors:  Changwei Shen; Jingping Yuan; Xingqi Ou; Xiujuan Ren; Xinhua Li
Journal:  PeerJ       Date:  2021-07-23       Impact factor: 2.984

10.  Influence of codon bias on heterologous production of human papillomavirus type 16 major structural protein L1 in yeast.

Authors:  Milda Norkiene; Alma Gedvilaite
Journal:  ScientificWorldJournal       Date:  2012-05-02
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