Literature DB >> 1339272

Cloning and characterization of the human thyroid hormone receptor beta 1 gene promoter.

A Sakurai1, T Miyamoto, L J DeGroot.   

Abstract

The promoter region of the human (h) thyroid hormone receptor (TR) beta 1 gene was isolated from a human placenta genomic library. Primer extension and S1 nuclease mapping confirmed a single transcriptional start site. DNA sequence analysis of the 5' upstream region revealed the existence of a putative thyroid response element (TRE) which is highly homologous to TREs found in several thyroid hormone responsive genes. Binding of hTR protein to the promoter region of the hTR beta 1 gene was confirmed by gel mobility shift assay. A transient transfection study demonstrated that hTR activated the expression of a reporter gene containing the promoter sequence of the hTR beta 1 gene in a hormone dependent manner. The TRE in the hTR beta 1 gene promoter may be involved in the autoregulation of hTR beta 1 gene expression.

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Year:  1992        PMID： 1339272     DOI： 10.1016/s0006-291x(05)80957-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

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Authors:  Pia Bagamasbad; Robert J Denver
Journal:  Gen Comp Endocrinol       Date:  2010-03-23       Impact factor: 2.822

2.  Transactivation of a cellular promoter by the NS1 protein of the parvovirus minute virus of mice through a putative hormone-responsive element.

Authors:  J M Vanacker; R Corbau; G Adelmant; M Perros; V Laudet; J Rommelaere
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103

3.  Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system.

Authors:  E D Abel; M E Boers; C Pazos-Moura; E Moura; H Kaulbach; M Zakaria; B Lowell; S Radovick; M C Liberman; F Wondisford
Journal:  J Clin Invest       Date:  1999-08       Impact factor: 14.808

4.  Maternal nutrient deprivation induces sex-specific changes in thyroid hormone receptor and deiodinase expression in the fetal guinea pig brain.

Authors:  Shiao Y Chan; Marcus H Andrews; Rania Lingas; Chris J McCabe; Jayne A Franklyn; Mark D Kilby; Stephen G Matthews
Journal:  J Physiol       Date:  2005-05-05       Impact factor: 5.182

5.  Alpha and beta thyroid hormone receptor (TR) gene expression during auditory neurogenesis: evidence for TR isoform-specific transcriptional regulation in vivo.

Authors:  D J Bradley; H C Towle; W S Young
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-18       Impact factor: 11.205

6.  Quantitation of beta 1 triiodothyronine receptor mRNA in human tissues by competitive reverse transcription polymerase chain reaction.

Authors:  S Meier-Heusler; A Pernin; H Liang; M O Goumaz; A G Burger; C A Meier
Journal:  J Endocrinol Invest       Date:  1995-11       Impact factor: 4.256

7.  A novel splice variant involving the 5' untranslated region of thyroid hormone receptor beta1 (TRbeta1).

Authors:  D Mannavola; L C Moeller; P Beck-Peccoz; L Persani; R E Weiss; S Refetoff
Journal:  J Endocrinol Invest       Date:  2004-04       Impact factor: 4.256

8.  A Mechanism to Enhance Cellular Responsivity to Hormone Action: Krüppel-Like Factor 9 Promotes Thyroid Hormone Receptor-β Autoinduction During Postembryonic Brain Development.

Authors:  Fang Hu; Joseph R Knoedler; Robert J Denver
Journal:  Endocrinology       Date:  2016-02-17       Impact factor: 4.736

9.  Epigenetic regulation of thyroid hormone receptor beta in renal cancer.

Authors:  Anna Wojcicka; Agnieszka Piekielko-Witkowska; Hanna Kedzierska; Beata Rybicka; Piotr Poplawski; Joanna Boguslawska; Adam Master; Alicja Nauman
Journal:  PLoS One       Date:  2014-05-21       Impact factor: 3.240
  9 in total

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