Literature DB >> 1338771

Expressed genes, Alu repeats and polymorphisms in cosmids sequenced from chromosome 4p16.3.

W R McCombie1, A Martin-Gallardo, J D Gocayne, M FitzGerald, M Dubnick, J M Kelley, L Castilla, L I Liu, S Wallace, S Trapp.   

Abstract

The sequences of three cosmids (90 kilobases) from the Huntington's disease region in chromosome 4p16.3 have been determined. A 30,837 base overlap of DNA sequenced from two individuals was found to contain 72 DNA sequence polymorphisms, an average of 2.3 polymorphisms per kilobase (kb). The assembled 58 kb contig contains 62 Alu repeats, and eleven predicted exons representing at least three expressed genes that encode previously unidentified proteins. Each of these genes is associated with a CpG island. The structure of one of the new genes, hda1-1, has been determined by characterizing cDNAs from a placental library. This gene is expressed in a variety of tissues and may encode a novel housekeeping gene.

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Year:  1992        PMID： 1338771     DOI： 10.1038/ng0892-348

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  9 in total

1.  The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding protein.

Authors:  F Martin; A Schaller; S Eglite; D Schümperli; B Müller
Journal:  EMBO J       Date:  1997-02-17       Impact factor: 11.598

2.  Multiplex genotype determination at a large number of gene loci.

Authors:  Z Lin; X Cui; H Li
Journal:  Proc Natl Acad Sci U S A       Date:  1996-03-19       Impact factor: 11.205

3.  Island rescue PCR: a rapid and efficient method for isolating transcribed sequences from yeast artificial chromosomes and cosmids.

Authors:  J M Valdes; D A Tagle; F S Collins
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-07       Impact factor: 11.205

Review 4.  Toward the complete genomic map and molecular pathology of human chromosome 4.

Authors:  O Riess; B Winkelmann; J T Epplen
Journal:  Hum Genet       Date:  1994-07       Impact factor: 4.132

5.  The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.

Authors:  A W Dangel; A R Mendoza; B J Baker; C M Daniel; M C Carroll; L C Wu; C Y Yu
Journal:  Immunogenetics       Date:  1994       Impact factor: 2.846

6.  Partial sequence analysis of 130 randomly selected maize cDNA clones.

Authors:  C S Keith; D O Hoang; B M Barrett; B Feigelman; M C Nelson; H Thai; C Baysdorfer
Journal:  Plant Physiol       Date:  1993-01       Impact factor: 8.340

7.  Number of CpG islands and genes in human and mouse.

Authors:  F Antequera; A Bird
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-15       Impact factor: 11.205

8.  Suppression of anchorage-independent growth after gene transfection.

Authors:  D J Winterbourne; S Thomas; J Hermon-Taylor
Journal:  Br J Cancer       Date:  1993-08       Impact factor: 7.640

9.  Concerted evolution of the tandem array encoding primate U2 snRNA occurs in situ, without changing the cytological context of the RNU2 locus.

Authors:  T Pavelitz; L Rusché; A G Matera; J M Scharf; A M Weiner
Journal:  EMBO J       Date:  1995-01-03       Impact factor: 11.598
  9 in total

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