Literature DB >> 1338649

Astrocytic localization of the messenger RNA encoding the isoenzyme B of inositol (1,4,5) 3-kinase in the human brain.

P Mailleux1, K Takazawa, N Albala, C Erneux, J J Vanderhaeghen.   

Abstract

The calcium-mobilizing second messenger inositol 1,4,5-trisphosphate (InsP3) is phosphorylated to inositol 1,3,4,5-tetrakisphosphate, another putative second messenger, through the activity of the enzyme InsP3 3-kinase. The cDNAs encoding two such isozymes have been recently isolated from a human hippocampal cDNAs library. We have previously reported the neuronal localization of the A form (Mailleux et al., Neurosci. Lett., 137 (1992) 69-71) and we here demonstrate the presence of the messenger RNA for the B form in human astrocytes.

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Year:  1992        PMID: 1338649     DOI: 10.1016/0304-3940(92)90833-s

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN: 0304-3940            Impact factor:   3.046


  3 in total

1.  Regulation of the localization and activity of inositol 1,4,5-trisphosphate 3-kinase B in intact cells by proteolysis.

Authors:  Jowie C H Yu; Samantha M Lloyd-Burton; Robin F Irvine; Michael J Schell
Journal:  Biochem J       Date:  2005-12-15       Impact factor: 3.857

2.  Enhanced hippocampal CA1 LTP but normal spatial learning in inositol 1,4,5-trisphosphate 3-kinase(A)-deficient mice.

Authors:  K Jun; G Choi; S G Yang; K Y Choi; H Kim; G C Chan; D R Storm; C Albert; G W Mayr; C J Lee; H S Shin
Journal:  Learn Mem       Date:  1998 Sep-Oct       Impact factor: 2.460

Review 3.  Inositol trisphosphate 3-kinases: focus on immune and neuronal signaling.

Authors:  Michael J Schell
Journal:  Cell Mol Life Sci       Date:  2010-01-12       Impact factor: 9.261

  3 in total

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