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Literature DB >> 13385407

Synthesis of sulfomucopolysaccharides in thyroidectomized rats.

Abstract

The thyroid glands of rats were made non-functional by a single dose of iodine-131 on the 1st day after birth or by surgical removal on the 28th day. The incorporation of sulfate-sulfur into the sulfomucopolysaccharides of skeletons and pelts was found to be significantly depressed by thyroidectomy. Daily supplements of 5 or 10 gamma of L-thyroxine, started on the 28th day, increased the uptake of sulfur-35, although it did not reach normal in the 2 weeks of treatment. Autoradiograms of sections of tibiae and pelts confirmed the analytical data. The findings suggest that the synthesis of sulfomucopolysaccharides is depressed in thyroidectomized rats.

Entities: Chemical Species

Keywords: MUCOPOLYSACCHARIDES/metabolism

Mesh：

Substances：

Year: 1957 PMID： 13385407 PMCID： PMC2136670 DOI： 10.1084/jem.105.1.69

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

5 in total

1. On the possible utilization of sulfate sulfur by the suckling rat for the synthesis of chondroitin sulfate as indicated by the use of radioactive sulfur.

Authors: D D DZIEWIATKOWSKI; R E BENESCH; R BENESCH
Journal: J Biol Chem Date: 1949-04 Impact factor: 5.157

2. Effect of thyroxine and thiouracil on S35 deposition in articular cartilage.

Authors: D D DZIEWIATKOWSKI
Journal: J Biol Chem Date: 1951-04 Impact factor: 5.157

3. Radioautographic visualization of sulfur-35 disposition in the articular cartilage and bone of suckling rats following injection of labeled sodium sulfate.

Authors: D D DZIEWIATKOWSKI
Journal: J Exp Med Date: 1951-05 Impact factor: 14.307

Synthesis of sulfomucopolysaccharides in thyroidectomized rats.

1. On the possible utilization of sulfate sulfur by the suckling rat for the synthesis of chondroitin sulfate as indicated by the use of radioactive sulfur.

2. Effect of thyroxine and thiouracil on S35 deposition in articular cartilage.

3. Radioautographic visualization of sulfur-35 disposition in the articular cartilage and bone of suckling rats following injection of labeled sodium sulfate.

4. Some endocrine influences on skeletal growth and differentiation.

5. Effect of age on some aspects of sulfate metabolism in the rat.

1. THE EFFECTS OF THIOURACIL ON GROWING CARTILAGE IN THE RAT.

Review 2. Hypothyroid myopathy: A peculiar clinical presentation of thyroid failure. Review of the literature.

3. The effect of prolonged prednisone treatment on human costal cartilage.

4. EFFECT OF HORMONES ON THE TURNOVER OF POLYSACCHARIDES IN CONNECTIVE TISSUES.

5. Endocrine dysfunction and slipped captial femoral epiphysis.