Literature DB >> 133846

Effect of 1-methyl-1-nitrosourea and streptozotocin on glucose-induced insulin secretion by isolated islets of Langerhans.

P Golden, L Baird, W J Malaisse, F Malaisse-Lagae, M M Walker.   

Abstract

The present experiments were designed to compare the effects of streptozotocin and 1-methyl-1-nitrosourea upon glucose-induced insulin secretion by isolated islets of Langerhans. Both drugs depressed the insulin response at one and two hours incubation but higher molar concentrations of the nitrosourea were required to produce the same level of inhibition as streptozotocin, a difference perhaps related to the latter's glucose moiety.

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Year:  1976        PMID： 133846     DOI： 10.1007/bf00422087

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  22 in total

1.  Studies on the diabetogenic action of streptozotocin (NSC-37917).

Authors:  N RAKIETEN; M L RAKIETEN; M V NADKARNI
Journal:  Cancer Chemother Rep       Date:  1963-05

2.  Plasma glucose levels in normal and adrenalectomized mice treated with streptozotocin and nicotinamide.

Authors:  P S Schein; R W Bates
Journal:  Diabetes       Date:  1968-12       Impact factor: 9.461

3.  1-methyl-1-nitrosourea and dialkylnitrosamine depression of nicotinamide adenine dinucleotide.

Authors:  P S Schein
Journal:  Cancer Res       Date:  1969-06       Impact factor: 12.701

4.  Streptozotocin: depression of mouse liver pyridine nucleotides.

Authors:  P S Schein; S Loftus
Journal:  Cancer Res       Date:  1968-08       Impact factor: 12.701

5.  Streptozotocin diabetes: time course of irreversible B-cell damage; further observations on prevention by nicotinamide.

Authors:  W Stauffacher; I Burr; A Gutzeit; D Beaven; J Veleminsky; A E Renold
Journal:  Proc Soc Exp Biol Med       Date:  1970-01

6.  Assay of partially neutralized guinea pig anti-insulin serum.

Authors:  P H Wright; W J Malaisse; I J Reynolds
Journal:  Endocrinology       Date:  1967-08       Impact factor: 4.736

7.  Diabetogenic effects of streptozotocin in rhesus monkeys.

Authors:  R M Pitkin; W A Reynolds
Journal:  Diabetes       Date:  1970-02       Impact factor: 9.461

8.  The structure of streptozotocin.

Authors:  R R Herr; J K Jahnke; A D Argoudelis
Journal:  J Am Chem Soc       Date:  1967-08-30       Impact factor: 15.419

9.  Diabetogenic effects of n-nitrosomethylurea in the chinese hamster.

Authors:  E Wilander; R Gunnarsson
Journal:  Acta Pathol Microbiol Scand A       Date:  1975-03

10.  Cytotoxic effects of streptozotocin and N-nitrosomethylurea on the pancreatic B cells with special regard to the role of nicotinamide-adenine dinucleotide.

Authors:  R Gunnarsson; C Berne; C Hellerström
Journal:  Biochem J       Date:  1974-06       Impact factor: 3.857
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  4 in total

1.  Strategies for reduction in the prevalence of NIDDM; the case for a population-based approach to the development of policies to deal with environmental factors in its aetiology.

Authors:  B J Boucher
Journal:  Diabetologia       Date:  1995-09       Impact factor: 10.122

2.  The potential mechanism of the diabetogenic action of streptozotocin: inhibition of pancreatic beta-cell O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase.

Authors:  R J Konrad; I Mikolaenko; J F Tolar; K Liu; J E Kudlow
Journal:  Biochem J       Date:  2001-05-15       Impact factor: 3.857

3.  Streptozotocin-induced FAD-glycerophosphate dehydrogenase suppression in pancreatic islets. Relationship with the severity and duration of hyperglycaemia and resistance to insulin or riboflavin treatment.

Authors:  J Rasschaert; W J Malaisse
Journal:  Acta Diabetol       Date:  1993       Impact factor: 4.280

4.  Protective action of Citrullus colocynthis seed extracts against the deleterious effect of streptozotocin on both in vitro glucose-stimulated insulin release from rat pancreatic islets and in vivo glucose homeostasis.

Authors:  Nabila Benariba; Wafaa Bellakdhar; Rabeh Djaziri; Emeline Hupkens; Karim Louchami; Willy J Malaisse
Journal:  Biomed Rep       Date:  2012-08-27
  4 in total

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