Literature DB >> 1338266

Induction by aerosol allergen of sustained and nonspecific IgE-mediated airway hyperreactivity in the guinea pig.

D A Handley1, J J DeLeo, A M Havill.   

Abstract

Described is a guinea pig model of allergic asthma, in which animals are sensitized by intraperitoneal injections of ovalbumin complexed with aluminum hydroxide to elicit an IgE response. Aerosol exposure to ovalbumin induces acute bronchoconstriction and nonspecific airways hyperreactivity, evaluated by intravenous challenges of histamine or acetylcholine. This model mimics the hallmark features of human asthma, is induced by respired allergen and is pharmacologically modulated by prophylactic drugs (methyl prednisolone, ketotifen, theophylline) and the competitive PAF receptor antagonist SDZ 264-412.

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Year:  1992        PMID： 1338266     DOI： 10.1007/bf02028109

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  7 in total

1.  The effect of the selective PAF antagonist BN 52021 on PAF- and antigen-induced bronchial hyper-reactivity and eosinophil accumulation.

Authors:  A J Coyle; S C Urwin; C P Page; C Touvay; B Villain; P Braquet
Journal:  Eur J Pharmacol       Date:  1988-03-22       Impact factor: 4.432

2.  Inflammatory mediators involved in antigen-induced airway microvascular leakage in guinea pigs.

Authors:  T W Evans; D F Rogers; B Aursudkij; K F Chung; P J Barnes
Journal:  Am Rev Respir Dis       Date:  1988-08

3.  Repeated antigen challenge induces airway hyperresponsiveness with tissue eosinophilia in guinea pigs.

Authors:  K Ishida; L J Kelly; R J Thomson; L L Beattie; R R Schellenberg
Journal:  J Appl Physiol (1985)       Date:  1989-09

4.  Inhibition of antigen-induced airway hyperresponsiveness, but not acute hypoxia nor airway eosinophilia, by an antagonist of platelet-activating factor.

Authors:  K Ishida; R J Thomson; L L Beattie; B Wiggs; R R Schellenberg
Journal:  J Immunol       Date:  1990-05-15       Impact factor: 5.422

5.  Interactions between granulocytes and platelets with the guinea-pig lung in passive anaphylactic shock. Correlations with PAF-acether-induced lesion.

Authors:  A Lellouch-Tubiana; J Lefort; A Pfister; B B Vargaftig
Journal:  Int Arch Allergy Appl Immunol       Date:  1987

6.  Prevention of non-specific airway hyperreactivity after allergen challenge in guinea-pigs by the PAF receptor antagonist SDZ 64-412.

Authors:  A M Havill; R G Van Valen; D A Handley
Journal:  Br J Pharmacol       Date:  1990-02       Impact factor: 8.739

7.  The booster injection of antigen during active sensitization of guinea-pig modifies the anti-anaphylactic activity of the PAF antagonist WEB 2086.

Authors:  S Desquand; J Lefort; C Dumarey; B B Vargaftig
Journal:  Br J Pharmacol       Date:  1990-06       Impact factor: 8.739
  7 in total
  3 in total

1.  Pharmaceutical dry powder aerosols: correlation of powder properties with dose delivery and implications for pharmacodynamic effect.

Authors:  N M Concessio; M M VanOort; M R Knowles; A J Hickey
Journal:  Pharm Res       Date:  1999-06       Impact factor: 4.200

Review 2.  Mechanisms of Heightened Airway Sensitivity and Responses to Inhaled SO2 in Asthmatics.

Authors:  Anita L Reno; Edward G Brooks; Bill T Ameredes
Journal:  Environ Health Insights       Date:  2015-04-01

Review 3.  The regulation of pulmonary immunity.

Authors:  M F Lipscomb; D E Bice; C R Lyons; M R Schuyler; D Wilkes
Journal:  Adv Immunol       Date:  1995       Impact factor: 3.543
  3 in total

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