| Literature DB >> 1338205 |
K P Singh1, S I Zaidi, S Raisuddin, A K Saxena, R C Murthy, P K Ray.
Abstract
The effect of zinc treatment on immune function and resistance against infection and tumor challenge was studied in mice. Swiss albino mice were treated with zinc acetate (3 mg/kg body weight) in one or two intraperitoneal injections. Various immune function assays were performed in treated animals. Zinc treatment to normal animals caused potentiation of T-lymphocyte and macrophage functions. Zinc treatment was also found to increase host resistance against Candida albicans and Semliki Forest virus infections. Increased resistance against endotoxin shock and Ehrlich's ascites tumor challenge was also observed in zinc treated animals. It can be stated from this study that zinc treatment potentiates the cell mediated immunity and host resistance against infection and tumor challenge.Entities:
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Year: 1992 PMID： 1338205 DOI： 10.3109/08923979209009237
Source DB: PubMed Journal: Immunopharmacol Immunotoxicol ISSN： 0892-3973 Impact factor: 2.730