J M Hamlyn1, P Manunta. 1. Department of Physiology, School of Medicine, University of Maryland, Baltimore 21201.
Abstract
PURPOSE: To review the evidence that ouabain and other digitalis-like factors are present in the human circulation under normal circumstances and in various disorders of fluid and electrolyte balance that are associated with hypertension. CONTENT: Recent evidence on a number of ouabain-related issues includes (1) evidence for the existence of inhibitors of sodium pumps in mammalian plasma, (2) the identification of one of these factors as ouabain, (3) measurements of plasma levels of ouabain in man, (4) evidence that ouabain causes chronic hypertension in rats and is associated with human hypertension, and (5) data on some probable mechanisms that may mediate the pressor effect. CONCLUSIONS: The available data support the novel hypothesis that ouabain is an endogenous circulating agent in man and other mammals and is likely to influence long-term blood pressure levels.
PURPOSE: To review the evidence that ouabain and other digitalis-like factors are present in the human circulation under normal circumstances and in various disorders of fluid and electrolyte balance that are associated with hypertension. CONTENT: Recent evidence on a number of ouabain-related issues includes (1) evidence for the existence of inhibitors of sodium pumps in mammalian plasma, (2) the identification of one of these factors as ouabain, (3) measurements of plasma levels of ouabain in man, (4) evidence that ouabain causes chronic hypertension in rats and is associated with humanhypertension, and (5) data on some probable mechanisms that may mediate the pressor effect. CONCLUSIONS: The available data support the novel hypothesis that ouabain is an endogenous circulating agent in man and other mammals and is likely to influence long-term blood pressure levels.
Authors: Mordecai P Blaustein; Frans H H Leenen; Ling Chen; Vera A Golovina; John M Hamlyn; Thomas L Pallone; James W Van Huysse; Jin Zhang; W Gil Wier Journal: Am J Physiol Heart Circ Physiol Date: 2011-11-04 Impact factor: 4.733
Authors: A Kawamura; J Guo; Y Itagaki; C Bell; Y Wang; G T Haupert; S Magil; R T Gallagher; N Berova; K Nakanishi Journal: Proc Natl Acad Sci U S A Date: 1999-06-08 Impact factor: 11.205
Authors: T Wasada; H Kuroki; M Naruse; H Arii; A Maruyama; K Katsumori; S Saito; Y Watanabe; K Naruse; H Demura Journal: Diabetologia Date: 1995-07 Impact factor: 10.122
Authors: Christopher A Drummond; Moustafa Sayed; Kaleigh L Evans; Huilin Shi; Xiaoliang Wang; Steven T Haller; Jiang Liu; Christopher J Cooper; Zijian Xie; Joseph I Shapiro; Jiang Tian Journal: Am J Physiol Heart Circ Physiol Date: 2014-04-18 Impact factor: 4.733