Literature DB >> 1337755

Expression of active human interferon-beta in transgenic plants.

O Edelbaum1, D Stein, N Holland, Y Gafni, O Livneh, D Novick, M Rubinstein, I Sela.   

Abstract

Tobacco plants were transformed with the human gene for interferon-beta (IFN-beta). Transformation was determined by the polymerase chain reaction (PCR), and expression was determined by Western blot analysis, by purifying the IFN from the transgenic plants, and by bioassays indicating its activity in human cells. Plants expressing IFN-beta were self-pollinated. IFN-beta-expressing progeny plants were selected and produced active IFN-beta, indicating stable transformation.

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Year:  1992        PMID： 1337755     DOI： 10.1089/jir.1992.12.449

Source DB:  PubMed          Journal:  J Interferon Res        ISSN： 0197-8357


  10 in total

Review 1.  Plants as bioreactors for protein production: avoiding the problem of transgene silencing.

Authors:  C De Wilde; H Van Houdt; S De Buck; G Angenon; G De Jaeger; A Depicker
Journal:  Plant Mol Biol       Date:  2000-06       Impact factor: 4.076

2.  Synthesis and expression of recombinant interferon alpha-5 gene in tobacco chloroplasts, a non-edible plant.

Authors:  Muhammad Sarwar Khan; Farwa Nurjis
Journal:  Mol Biol Rep       Date:  2011-09-22       Impact factor: 2.316

3.  High-level expression of human interferon alpha-2b in transgenic carrot (Daucus carota L.) plants.

Authors:  Yu Luchakivskaya; O Kishchenko; I Gerasymenko; Z Olevinskaya; Yu Simonenko; M Spivak; M Kuchuk
Journal:  Plant Cell Rep       Date:  2010-11-03       Impact factor: 4.570

4.  Field production and functional evaluation of chloroplast-derived interferon-alpha2b.

Authors:  Philip A Arlen; Regina Falconer; Sri Cherukumilli; Amy Cole; Alexander M Cole; Karen K Oishi; Henry Daniell
Journal:  Plant Biotechnol J       Date:  2007-05-09       Impact factor: 9.803

5.  Expression of anti human IL-4 and IL-6 scFvs in transgenic tobacco plants.

Authors:  P Ehsani; A Meunier; F Nato; A Jafari; A Nato; P Lafaye
Journal:  Plant Mol Biol       Date:  2003-05       Impact factor: 4.076

Review 6.  Recombinant cytokines from plants.

Authors:  Agnieszka Sirko; Tomas Vaněk; Anna Góra-Sochacka; Patrycja Redkiewicz
Journal:  Int J Mol Sci       Date:  2011-06-03       Impact factor: 5.923

7.  Rapid high-yield expression of a candidate influenza vaccine based on the ectodomain of M2 protein linked to flagellin in plants using viral vectors.

Authors:  Eugenia S Mardanova; Roman Y Kotlyarov; Victor V Kuprianov; Liudmila A Stepanova; Liudmila M Tsybalova; George P Lomonosoff; Nikolai V Ravin
Journal:  BMC Biotechnol       Date:  2015-05-29       Impact factor: 2.563

8.  Efficient Transient Expression of Recombinant Proteins in Plants by the Novel pEff Vector Based on the Genome of Potato Virus X.

Authors:  Eugenia S Mardanova; Elena A Blokhina; Liudmila M Tsybalova; Hadrien Peyret; George P Lomonossoff; Nikolai V Ravin
Journal:  Front Plant Sci       Date:  2017-02-28       Impact factor: 5.753

Review 9.  Chloroplast-derived vaccine antigens and biopharmaceuticals: expression, folding, assembly and functionality.

Authors:  S Chebolu; H Daniell
Journal:  Curr Top Microbiol Immunol       Date:  2009       Impact factor: 4.291

10.  Expression of the Biologically Active Insulin Analog SCI-57 in Nicotiana Benthamiana.

Authors:  Adriana Muñoz-Talavera; Miguel Ángel Gómez-Lim; Luis A Salazar-Olivo; Jörg Reinders; Katharina Lim; Abraham Escobedo-Moratilla; Alberto Cristian López-Calleja; María Cristina Islas-Carbajal; Ana Rosa Rincón-Sánchez
Journal:  Front Pharmacol       Date:  2019-11-14       Impact factor: 5.810
  10 in total

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