Literature DB >> 1337350

The bactericidal activity of sparfloxacin.

C S Lewin1, I Morrissey, J T Smith.   

Abstract

Sparfloxacin was found to display a biphasic response against Escherichia coli, Staphylococcus aureus and Staphylococcus epidermidis in nutrient broth. Its optimum bactericidal concentration was found to be identical for all three species which contrasts with other clinically available fluoroquinolones that are more active against E. coli than against staphylococci. Bacterial protein and RNA synthesis as well as cell division were not found to be essential for all the lethality of sparfloxacin, which hence displays bactericidal mechanism B. However, sparfloxacin was unable to kill bacteria in absence of oxygen.

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Year:  1992        PMID： 1337350     DOI： 10.1093/jac/30.5.625

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  7 in total

Review 1.  Quinolone-mediated bacterial death.

Authors:  Karl Drlica; Muhammad Malik; Robert J Kerns; Xilin Zhao
Journal:  Antimicrob Agents Chemother       Date:  2007-08-27       Impact factor: 5.191

2.  Pharmacodynamic properties of BAY 12-8039 on gram-positive and gram-negative organisms as demonstrated by studies of time-kill kinetics and postantibiotic effect.

Authors:  F J Boswell; J M Andrews; R Wise
Journal:  Antimicrob Agents Chemother       Date:  1997-06       Impact factor: 5.191

3.  Study of comparative antipneumococcal activities of penicillin G, RP 59500, erythromycin, sparfloxacin, ciprofloxacin, and vancomycin by using time-kill methodology.

Authors:  G A Pankuch; M R Jacobs; P C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  1994-09       Impact factor: 5.191

4.  Accumulation of norfloxacin by Bacteroides fragilis.

Authors:  V Ricci; L J Piddock
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

5.  In vitro activities of fluoroquinolones against the spirochete Borrelia burgdorferi.

Authors:  P Kraiczy; J Weigand; T A Wichelhaus; P Heisig; H Backes; V Schäfer; G Acker; V Brade; K P Hunfeld
Journal:  Antimicrob Agents Chemother       Date:  2001-09       Impact factor: 5.191

Review 6.  Antimicrobial susceptibility of Borrelia burgdorferi sensu lato: what we know, what we don't know, and what we need to know.

Authors:  Klaus-Peter Hunfeld; Volker Brade
Journal:  Wien Klin Wochenschr       Date:  2006-11       Impact factor: 1.704

7.  Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones.

Authors:  Muhammad Malik; Arkady Mustaev; Heidi A Schwanz; Gan Luan; Nirali Shah; Lisa M Oppegard; Ernane C de Souza; Hiroshi Hiasa; Xilin Zhao; Robert J Kerns; Karl Drlica
Journal:  Nucleic Acids Res       Date:  2016-03-16       Impact factor: 16.971
  7 in total

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