| Literature DB >> 1337194 |
V Tancredi1, G D'Arcangelo, F Grassi, P Tarroni, G Palmieri, A Santoni, F Eusebi.
Abstract
The effects of human recombinant tumor necrosis factor (TNF-alpha) on the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. Population spikes and/or excitatory postsynaptic potentials were extracellularly recorded in hippocampus CA1 region from stratum pyramidale and stratum radiatum, respectively, and synaptic transmission was examined in the Schaffer collateral/commissural-CA1 pathway. Basal neurotransmission slightly and promptly increased in slices acutely exposed to TNF-alpha (1-100 nM). Examination of the long-term potentiation (LTP) revealed that a brief treatment with the cytokine did not influence LTP, while a long-lasting application of TNF-alpha (50 min or more) inhibited LTP in a dose-dependent way in the range of 1-100 nM. A role for TNF-alpha as a peptide of immunological significance belonging to the family of brain neuromodulators is discussed.Entities:
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Year: 1992 PMID： 1337194 DOI： 10.1016/0304-3940(92)90071-e
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046