Literature DB >> 1336926

Lipid-independent therapeutic properties of transdermal 17 B-estradiol on cardiovascular diseases.

A Cagnacci1, R Soldani, E Puccini, P Fioretti, G B Melis.   

Abstract

A low dose of transdermally administered 17 B-estradiol promptly improved a severe, treatment-unresponsive, cardiac arrhythmia initiated after the menopause in a woman with type-II familial hyperlipoproteinemia. The same treatment normalized the hypertension initiated after ovariectomy, in a woman who was only poorly controlled by anti-hypertensive drugs. These two cases are the first clear report of cardiovascular therapeutic properties of transdermal estradiol via mechanisms independent of lipoprotein modifications.

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Year:  1992        PMID: 1336926     DOI: 10.3109/00016349209006235

Source DB:  PubMed          Journal:  Acta Obstet Gynecol Scand        ISSN: 0001-6349            Impact factor:   3.636


  2 in total

Review 1.  Hormone replacement therapy: II. A pharmacoeconomic appraisal of its role in the prevention of postmenopausal osteoporosis and ischaemic heart disease.

Authors:  R Whittington; D Faulds
Journal:  Pharmacoeconomics       Date:  1994-06       Impact factor: 4.981

2.  Increased expression of the cardiac L-type calcium channel in estrogen receptor-deficient mice.

Authors:  B D Johnson; W Zheng; K S Korach; T Scheuer; W A Catterall; G M Rubanyi
Journal:  J Gen Physiol       Date:  1997-08       Impact factor: 4.086

  2 in total

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