| Literature DB >> 1336765 |
S Cinque1, J Willems, S Depraetere, L Vermeire, M Joniau.
Abstract
The human glioma cell lines U251 and HP591 were chosen as "in vitro" models for functional astrocytes. When cultured in the presence of IL-1 beta these cell lines demonstrated a marked increase in interleukin-6 production and in [3H]-thymidine uptake. The addition of dbcAMP could mimic the first effect of IL-1 beta but at the same time suppressed cell proliferation. These results suggest that IL-1 beta possibly exerts one of its biological effects (IL-6 synthesis) by means of the cyclic AMP pathway.Entities:
Mesh：
Substances：
Year: 1992 PMID： 1336765 DOI： 10.1016/0165-2478(92)90223-b
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685