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Literature DB >> 13367340

Immunohistochemical analysis of amyloid by the fluorescence technique.

Abstract

The immunohistochemical composition of amyloid deposits in secondary human amyloidosis and experimental amyloidosis in rabbits was studied by means of the "fluorescent antibody" technique of Coons et al. Quantitative studies of the relative amounts of gamma globulin present in the amyloid deposits by the use of radioiodinated fluorescent antibody are reported. It is concluded that amyloid deposits in several organs from cases of secondary human amyloidosis and experimental amyloidosis in rabbits contain considerable concentrations of gamma globulin. The presence of gamma globulin in amyloid might be interpreted as either a metabolic deposition of circulating globulin present in high concentrations in the plasma or as a result of an immunologic reaction involving antigen and antibody.

Entities: Disease Species

Keywords: AMYLOIDOSIS/pathology; GAMMA GLOBULIN/determination

Mesh：

Substances：

Year: 1956 PMID： 13367340 PMCID： PMC2136616 DOI： 10.1084/jem.104.5.727

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

6 in total

1. Studies of the composition of secondary amyloid.

Authors: R B GILES; E CALKINS
Journal: J Clin Invest Date: 1955-09 Impact factor: 14.808

2. On the amyloid-Congo red complex in histological sections and the genesis of the amyloid substance.

Authors: G A JOHANSSON; H H PFEIFFER
Journal: Acta Anat (Basel) Date: 1954

3. Allergic hyperglobulinosis and hyalinosis (paramyloidosis) in the reticulo-endothelial system in Boeck's sarcoid and other conditions; a morphologic immunity reaction.

Authors: G TEILUM
Journal: Am J Pathol Date: 1948-03 Impact factor: 4.307

51 in total

1. EXPERIMENTAL AMYLOIDOSIS IN MICE; A PATHO-SEROLOGICAL STUDY.

Authors: C TAL; A LAUFER; A ZLOTNICK
Journal: Br J Exp Pathol Date: 1964-06

2. Glomerular excretion of macromolecular substances. Electron microscopic study of rat kidney after administration of human serum albumin.

Authors: C T ASHWORTH; J A JAMES
Journal: Am J Pathol Date: 1961-09 Impact factor: 4.307

Immunohistochemical analysis of amyloid by the fluorescence technique.

1. Studies of the composition of secondary amyloid.

2. On the amyloid-Congo red complex in histological sections and the genesis of the amyloid substance.

3. Allergic hyperglobulinosis and hyalinosis (paramyloidosis) in the reticulo-endothelial system in Boeck's sarcoid and other conditions; a morphologic immunity reaction.

4. Primary systemic amyloidosis.

5. Antigen elimination from the blood as an early manifestation of the immune response.

6. Fluorescein-conjugated bovine albumin; physical and biological properties.

1. EXPERIMENTAL AMYLOIDOSIS IN MICE; A PATHO-SEROLOGICAL STUDY.

2. Glomerular excretion of macromolecular substances. Electron microscopic study of rat kidney after administration of human serum albumin.

3. DIFFUSE TRACHEO-BRONCHIAL AMYLOIDOSIS: A RARE VARIANT OF A PROTEAN DISEASE.

4. ELECTRON MICROSCOPIC STUDIES OF AMYLOID FIBRILS WITH FERRITINCONJUGATED ANTIBODY.

5. THE SITE OF FORMATION AND ULTRASTRUCTURE OF AMYLOID.

6. SERUM PROTEIN PATTERNS ASSOCIATED WITH AMYLOIDOSIS IN THE SYRIAN HAMSTER.

7. EXPERIMENTAL AMYLOIDOSIS: STUDIES WITH A MODIFIED CASEIN METHOD, CASEIN HYDROLYSATE AND GELATIN.

8. [ON THE BIOCHEMISTRY OF AMYLOID].

9. Amyloidosis of functioning islet cell adenomas of the pancreas.

10. Observations on the differing nature of the DNA of lymphocytes and neutrophile leucocytes.