Literature DB >> 13367

Inhibitors of genetic recombination in pneumococci.

H Seto, A Tomasz.   

Abstract

Treatment of transformable pneumococci with DNA-intercalating agents shortly after the uptake of DNA molecules inhibited the appearance of genetic transformants. The same drug treatments applied 20 min after DNA uptake were ineffective. Ethidium bromide, proflavin, daunomycin, actinomycin D, and platinum red were found to be effective inhibitors. Donor DNA molecules reisolated from the drug-treated bacteria appeared to be associated with the resident DNA in an abnormal manner, and they had only poor transforming activity.

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Year:  1977        PMID： 13367      PMCID： PMC393246          DOI： 10.1073/pnas.74.1.296

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

1.  X-ray fiber diffraction evidence for neighbor exclusion binding of a platinum metallointercalation reagent to DNA.

Authors:  P J Bond; R Langridge; K W Jennette; S J Lippard
Journal:  Proc Natl Acad Sci U S A       Date:  1975-12       Impact factor: 11.205

2.  Molecular fate of DNA in genetic transformation of Pneumococcus.

Authors:  S LACKS
Journal:  J Mol Biol       Date:  1962-07       Impact factor: 5.469

3.  Fate of donor deoxyribonucleic acid in a highly transformation-deficient strain of Haemophilus influenzae.

Authors:  J Kooistra; G Venema
Journal:  J Bacteriol       Date:  1974-09       Impact factor: 3.490

4.  Model for the mechanism controlling the expression of competent state in Pneumococcus cultures.

Authors:  A Tomasz
Journal:  J Bacteriol       Date:  1966-03       Impact factor: 3.490

5.  Cellular metabolism in genetic transformation of pneumococci: requirement for protein synthesis during induction of competence.

Authors:  A Tomasz
Journal:  J Bacteriol       Date:  1970-03       Impact factor: 3.490

6.  Adenosine triphosphate-dependent deoxyribonuclease from Diplococcus pneumoniae: fate of transforming deoxyribonucleic acid in a strain deficient in the enzymatic activity.

Authors:  G F Vovis
Journal:  J Bacteriol       Date:  1973-02       Impact factor: 3.490

7.  Early stages in DNA binding and uptake during genetic transformation of pneumococci.

Authors:  H Seto; A Tomasz
Journal:  Proc Natl Acad Sci U S A       Date:  1974-04       Impact factor: 11.205

8.  Role of a deoxyribonuclease in the genetic transformation of Diplococcus pneumoniae.

Authors:  S Lacks; B Greenberg; M Neuberger
Journal:  Proc Natl Acad Sci U S A       Date:  1974-06       Impact factor: 11.205

9.  Antimicrobial spectrum of Triclosan, a broad-spectrum antimicrobial agent for topical application.

Authors:  W A Vischer; J Regös
Journal:  Zentralbl Bakteriol Orig A       Date:  1974-03

10.  Competence mutants. II. Physical and biological fate of donor transforming deoxyribonucleic acid.

Authors:  E H Postel; S H Goodgal
Journal:  J Bacteriol       Date:  1972-01       Impact factor: 3.490
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  4 in total

1.  Lethal effect of protamine and histone on competent Bacillus subtilis cells. Inhibition of genetic transformation by protamine in sublethal concentration.

Authors:  S Antohi; A Popescu
Journal:  Mol Gen Genet       Date:  1979-03-05

2.  Genetic transformation of Streptococcus pneumoniae by heterologous plasmid deoxyribonucleic acid.

Authors:  F Barany; A Tomasz
Journal:  J Bacteriol       Date:  1980-11       Impact factor: 3.490

3.  Interaction of phenylthiolato-(2,2',2"-terpyridine)platinum(II) cation with DNA.

Authors:  L P Wakelin; W D McFadyen; A Walpole; I A Roos
Journal:  Biochem J       Date:  1984-08-15       Impact factor: 3.857

4.  Translocation of the pre-synaptic complex formed upon DNA uptake by Streptococcus sanguis and its inhibition by ethidium bromide.

Authors:  J L Raina; E Metzer; A W Ravin
Journal:  Mol Gen Genet       Date:  1979-03-05
  4 in total

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