Literature DB >> 1336604

Anti-inflammatory activity of gallic acid.

B H Kroes1, A J van den Berg, H C Quarles van Ufford, H van Dijk, R P Labadie.   

Abstract

Gallic acid was found to possess antiinflammatory activity towards zymosan-induced acute food pad swelling in mice. In vitro studies on the mode of action of gallic acid revealed that this compound interferes with the functioning of polymorphonuclear leukocytes (PMNs). Scavenging of superoxide anions, inhibition of myeloperoxidase release and activity as well as a possible interference with the assembly of active NADPH-oxidase may account for the inhibition of inflammatory process by gallic acid. Structure-activity relationship analysis showed that the o-dihydroxy group of gallic acid is important for the inhibitory activity in vitro.

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Year:  1992        PMID： 1336604     DOI： 10.1055/s-2006-961535

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  79 in total

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