Literature DB >> 1336549

[Synthesis and benzodiazepine receptor binding studies of pyridazino[3,4-b]indoles].

Y Shimoji1, K Tomita, T Karube, T Kamioka.   

Abstract

A series of methyl 9H-pyridazino[3,4-b]indole-3-carboxylates and related compounds were synthesized using a Diels-Alder reaction of methyl 3-(1H-indol-3-yl)-2-propenoates and dibenzyl azodicarboxylate. Several compounds were found to have high affinity for the benzodiazepine receptor. Their structure-activity relationships are discussed.

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Year:  1992        PMID: 1336549     DOI: 10.1248/yakushi1947.112.11_804

Source DB:  PubMed          Journal:  Yakugaku Zasshi        ISSN: 0031-6903            Impact factor:   0.302


  1 in total

1.  Construction of Unusual Indole-Based Heterocycles from Tetrahydro-1H-pyridazino[3,4-b]indoles.

Authors:  Cecilia Ciccolini; Lucia De Crescentini; Fabio Mantellini; Giacomo Mari; Stefania Santeusanio; Gianfranco Favi
Journal:  Molecules       Date:  2020-09-09       Impact factor: 4.411

  1 in total

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