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Literature DB >> 1336397

Protein phosphatase X has been highly conserved during mammalian evolution.

Abstract

Complementary DNA encoding human protein phosphatase X (PPX, also designated PPP4 in the human genome nomenclature) was isolated from a teratocarcinoma library. The deduced amino acid sequence of human PPX differs from that of rabbit PPX in only two in 307 amino acids, demonstrating that the structure of PPX has been highly conserved during the course of mammalian evolution.

Entities: Disease Gene Species

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Year: 1992 PMID： 1336397 DOI： 10.1016/0167-4781(92)90129-n

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

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Cited

11 in total

1. Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptor.

Authors: M Chinkers
Journal: Proc Natl Acad Sci U S A Date: 1994-11-08 Impact factor: 11.205

2. The Arabidopsis thaliana PPX/PP4 phosphatases: molecular cloning and structural organization of the genes and immunolocalization of the proteins to plastids.

Authors: G Pujol; T I Baskin; A Casamayor; N Cortadellas; A Ferrer; J Ariño
Journal: Plant Mol Biol Date: 2000-11 Impact factor: 4.076

3. A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres.

Authors: C J Hastie; G K Carnegie; N Morrice; P T Cohen
Journal: Biochem J Date: 2000-05-01 Impact factor: 3.857

Review 4. The phospho-landscape of the survival of motoneuron protein (SMN) protein: relevance for spinal muscular atrophy (SMA).

Authors: Nora Tula Detering; Tobias Schüning; Niko Hensel; Peter Claus
Journal: Cell Mol Life Sci Date: 2022-08-25 Impact factor: 9.207

Protein phosphatase X has been highly conserved during mammalian evolution.

1. Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptor.

2. The Arabidopsis thaliana PPX/PP4 phosphatases: molecular cloning and structural organization of the genes and immunolocalization of the proteins to plastids.

3. A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres.

Review 4. The phospho-landscape of the survival of motoneuron protein (SMN) protein: relevance for spinal muscular atrophy (SMA).

5. Identification and molecular cloning of two homologues of protein phosphatase X from Arabidopsis thaliana.

6. PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4.

7. Protein phosphatase 4 plays dual roles during cell proliferation.

8. Kinetoplastid PPEF phosphatases: dual acylated proteins expressed in the endomembrane system of Leishmania.

9. Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells.

10. PPX, a novel protein serine/threonine phosphatase localized to centrosomes.