Literature DB >> 1335881

gamma-Hydroxybutyrate depresses monosynaptic excitatory and inhibitory postsynaptic potentials in rat hippocampal slices.

X Xie1, T G Smart.   

Abstract

The action of gamma-hydroxybutyrate was studied on pre- and postsynaptic GABA(B) receptors in rat hippocampal neurones in vitro using intracellular recording. gamma-Hydroxybutyrate (1-10 mM) caused a 4-8 mV hyperpolarization of CA1 cells and a 20-80% decrease in monosynaptic excitatory and inhibitory postsynaptic potentials in a concentration-dependent manner. These actions were reversibly inhibited by a novel and selective GABA(B) antagonist, CGP 36742 (20-500 microM) suggesting that gamma-hydroxybutyrate can activate presynaptic as well as postsynaptic GABA(B) receptors.

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Year:  1992        PMID： 1335881     DOI： 10.1016/0014-2999(92)94839-n

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Direct activation of G-protein-gated inward rectifying K+ channels promotes nonrapid eye movement sleep.

Authors:  Bende Zou; William S Cao; Zhiwei Guan; Kui Xiao; Conrado Pascual; Julian Xie; Jingxi Zhang; James Xie; Frank Kayser; Craig W Lindsley; C David Weaver; Jidong Fang; Xinmin Simon Xie
Journal:  Sleep       Date:  2019-03-01       Impact factor: 5.849

2.  The GABAB-receptor antagonist, CGP 35348, antagonises gamma-hydroxybutyrate- and baclofen-induced alterations in locomotor activity and forebrain dopamine levels in mice.

Authors:  H Nissbrandt; G Engberg
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

3.  Gammahydroxybutyrate (GHB) receptor ligand effects on evoked synaptic field potentials in CA1 of the rat hippocampal slice.

Authors:  M A King; J S Thinschmidt; D W Walker
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

4.  Pathway-specific action of gamma-hydroxybutyric acid in sensory thalamus and its relevance to absence seizures.

Authors:  Nicolas Gervasi; Zohreh Monnier; Pierre Vincent; Daniele Paupardin-Tritsch; Stuart W Hughes; Vincenzo Crunelli; Nathalie Leresche
Journal:  J Neurosci       Date:  2003-12-10       Impact factor: 6.167

5.  Effects of gamma hydroxybutyric acid on inhibition and excitation in rat neocortex.

Authors:  Q Li; C M Kuhn; W A Wilson; D V Lewis
Journal:  Neuroscience       Date:  2007-08-28       Impact factor: 3.590

Review 6.  A critical evaluation of the gamma-hydroxybutyrate (GHB) model of absence seizures.

Authors:  Marcello Venzi; Giuseppe Di Giovanni; Vincenzo Crunelli
Journal:  CNS Neurosci Ther       Date:  2014-11-18       Impact factor: 5.243
  6 in total

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