Literature DB >> 1335874

Nitric oxide donors increase mucus gel thickness in rat stomach.

J F Brown1, P J Hanson, B J Whittle.   

Abstract

Instillation of the nitric oxide (NO) generator isosorbide dinitrate (0.1-1 mM) into the rat gastric lumen in vivo produced a dose-related increase in mucus gel thickness that was prevented by coadministration of oxyhaemoglobin (10 microM). Isosorbide dinitrate did not induce epithelial cell damage. S-Nitroso-N-acetyl-penicillamine (0.3 mM) and dibutyryl cyclic GMP (1 mM) also increased mucus thickness. These findings, along with the presence of NO synthase in the gastric mucosa, imply a role for NO in vivo in mediation of gastric mucus release.

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Year:  1992        PMID： 1335874     DOI： 10.1016/0014-2999(92)90824-n

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  39 in total

1.  Regional differences of H+, HCO3-, and CO2 diffusion through native porcine gastroduodenal mucus.

Authors:  S Tanaka; H H J Meiselman; E Engel; P H Guth; O Furukawa; R B Wenby; J Lee; J D Kaunitz
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Review 2.  Asymmetric dimethylarginine: a novel biomarker of gastric mucosal injury?

Authors:  Zhe Zhang; Yi-You Zou; Fu-Jun Li; Chang-Ping Hu
Journal:  World J Gastroenterol       Date:  2011-05-07       Impact factor: 5.742

3.  Role of L-arginine, a substrate for nitric oxide-synthase, in gastroprotection and ulcer healing.

Authors:  T Brzozowski; S J Konturek; Z Sliwowski; D Drozdowicz; M Zaczek; D Kedra
Journal:  J Gastroenterol       Date:  1997-08       Impact factor: 7.527

4.  Mechanisms of gastroprotection by transdermal nitroglycerin in the rat.

Authors:  S Calatayud; M J Sanz; A Canet; R Bello; F D de Rojas; J V Esplugues
Journal:  Br J Pharmacol       Date:  1999-07       Impact factor: 8.739

5.  Histological study of mechanisms of adaptive cytoprotection on ethanol-induced mucosal damage in rat stomachs.

Authors:  J K Ko; C H Cho
Journal:  Dig Dis Sci       Date:  1998-06       Impact factor: 3.199

Review 6.  Gaseous Mediators in Gastrointestinal Mucosal Defense and Injury.

Authors:  John L Wallace; Angela Ianaro; Gilberto de Nucci
Journal:  Dig Dis Sci       Date:  2017-07-21       Impact factor: 3.199

7.  Comparison between 3-Nitrooxyphenyl acetylsalicylate (NO-ASA) and O2-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (NONO-ASA) as safe anti-inflammatory, analgesic, antipyretic, antioxidant prodrugs.

Authors:  Mitali Chattopadhyay; Carlos A Velazquez; April Pruski; Kamran V Nia; Khaled R Abdellatif; Larry K Keefer; Khosrow Kashfi
Journal:  J Pharmacol Exp Ther       Date:  2010-08-02       Impact factor: 4.030

8.  Sensitizing effects of lafutidine on CGRP-containing afferent nerves in the rat stomach.

Authors:  Katsushi Nishihara; Yoshihisa Nozawa; Motoko Nakano; Hirofusa Ajioka; Naosuke Matsuura
Journal:  Br J Pharmacol       Date:  2002-03       Impact factor: 8.739

Review 9.  Nitric oxide in the gastrointestinal tract: opportunities for drug development.

Authors:  John L Wallace
Journal:  Br J Pharmacol       Date:  2018-12-03       Impact factor: 8.739

10.  Expression of nitric oxide synthase in mucosal cells of the canine colon.

Authors:  S Torihashi; B Horowitz; J S Pollock; S M Ward; C Xue; S Kobayashi; K M Sanders
Journal:  Histochem Cell Biol       Date:  1996-01       Impact factor: 4.304
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