| Literature DB >> 1335858 |
O F Brouwer1, W Onkenhout, P M Edelbroek, J F de Kom, F A de Wolff, A C Peters.
Abstract
A 16-year-old girl from Surinam presented with mental deterioration and severe paraparesis with areflexia and bilateral Babinski signs. Laboratory examination showed a hyperhomocysteinemia that was caused by 5,10-methylene-tetrahydrofolate reductase (MTHFR) deficiency. In addition, urine samples contained large amounts of arsenic. An open bag with the pesticide copper acetate arsenite was found to be the source of exposure. In remethylation defects such as MTHFR deficiency, the concentration of methyldonors is severely reduced. As arsenic is detoxified by methylation, we suggest that the MTHFR deficiency in this girl might explain the fact that of all family members exposed to arsenic, only she developed severe clinical signs and symptoms of arsenic poisoning.Entities:
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Year: 1992 PMID： 1335858 DOI： 10.1016/0303-8467(92)90179-7
Source DB: PubMed Journal: Clin Neurol Neurosurg ISSN： 0303-8467 Impact factor: 1.876