Literature DB >> 1335594

Increased prostaglandin E2 and cAMP phosphodiesterase levels in Kaposi's sarcoma--a virus against host defense mechanism.

J L Ambrus1, H L Stoll, E A Klein, C P Karakousis, S Stadler.   

Abstract

In Kaposi's sarcoma tissue, prostaglandin E2 (PgE2) levels and cAMP phosphodiesterase levels were found to be higher than in surrounding normal tissue. We have shown earlier that PgE2 suppresses interferon (IFN) alpha production. High levels of cAMP phosphodiesterases result in low cAMP levels. Thus, this phenomenon may be involved in altered immunologic resistance, growth and differentiation.

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Year:  1992        PMID： 1335594

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN： 0034-5164


  7 in total

1.  Cyclooxygenase 2 induced by Kaposi's sarcoma-associated herpesvirus early during in vitro infection of target cells plays a role in the maintenance of latent viral gene expression.

Authors:  Neelam Sharma-Walia; Hari Raghu; Sathish Sadagopan; Ramu Sivakumar; Mohanan Valiya Veettil; Pramod P Naranatt; Marilyn M Smith; Bala Chandran
Journal:  J Virol       Date:  2006-07       Impact factor: 5.103

2.  Kaposi's sarcoma associated herpes virus (KSHV) induced COX-2: a key factor in latency, inflammation, angiogenesis, cell survival and invasion.

Authors:  Neelam Sharma-Walia; Arun George Paul; Virginie Bottero; Sathish Sadagopan; Mohanan Valiya Veettil; Nagaraj Kerur; Bala Chandran
Journal:  PLoS Pathog       Date:  2010-02-12       Impact factor: 6.823

3.  IgA from HIV+ haemophilic patients triggers intracellular signals coupled to the cholinergic system of the intestine.

Authors:  M E Sales; L Sterin-Borda; M M de Bracco; M Rodriguez; M Narbaitz; E Borda
Journal:  Clin Exp Immunol       Date:  1997-11       Impact factor: 4.330

4.  Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma.

Authors:  Stéphanie Dupuy; Marion Lambert; David Zucman; Siméon-Pierre Choukem; Sara Tognarelli; Cécile Pages; Céleste Lebbé; Sophie Caillat-Zucman
Journal:  PLoS Pathog       Date:  2012-01-12       Impact factor: 6.823

5.  Therapeutic effect of interleukin 12 on mouse haemangiosarcomas is not associated with an increased anti-tumour cytotoxic T-lymphocyte activity.

Authors:  C Vizler; A Rosato; F Calderazzo; L Quintieri; P Fruscella; R Wainstok de Calmanovici; A Mantovani; A Vecchi; P Zanovello; D Collavo
Journal:  Br J Cancer       Date:  1998-02       Impact factor: 7.640

6.  Kaposi's sarcoma associated herpesvirus G-protein coupled receptor activation of cyclooxygenase-2 in vascular endothelial cells.

Authors:  Bryan D Shelby; Heather L LaMarca; Harris E McFerrin; Anne B Nelson; Joseph A Lasky; Gang Sun; Leslie Myatt; Margaret K Offermann; Cindy A Morris; Deborah E Sullivan
Journal:  Virol J       Date:  2007-09-14       Impact factor: 4.099

7.  The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells.

Authors:  Darya A Haas; Kiran Bala; Guntram Büsche; Magdalena Weidner-Glunde; Susann Santag; Semra Kati; Silvia Gramolelli; Modester Damas; Oliver Dittrich-Breiholz; Michael Kracht; Jessica Rückert; Zoltan Varga; György Keri; Thomas F Schulz
Journal:  PLoS Pathog       Date:  2013-11-07       Impact factor: 6.823
  7 in total

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