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Literature DB >> 1335517

Crystallization and preliminary X-ray analysis of three serotypes of foot-and-mouth disease virus.

S Curry¹, R Abu-Ghazaleh, W Blakemore, E Fry, T Jackson, A King, S Lea, D Logan, J Newman, D Stuart.

Abstract

Foot-and-mouth disease viruses from serotypes O, A and C have been crystallized. The particular strains studied include O1K, A10(61), A22 Iraq 24/64, A24 Cruzeiro and C-S8c1. In addition, crystals have been grown of G67, a monoclonal antibody neutralization escape mutant derived from O1K, and of virus R100, recovered after the establishment of a persistent infection in baby hamster kidney cells with C-S8c1. Empty particles, capsids which lack the RNA genome, have also been crystallized for subtypes A22 Iraq 24/64 and A10(61). In almost all cases, crystals suitable for high resolution structure determination were obtained from (NH4)2SO4 or mixtures of polyethylene glycol and NH4Cl.

Entities: Chemical Disease Species

Mesh：

Substances：
Trypsin

Year: 1992 PMID： 1335517 DOI： 10.1016/0022-2836(92)90332-e

Source DB: PubMed Journal: J Mol Biol ISSN： 0022-2836 Impact factor: 5.469

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Cited

5 in total

1. Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus.

Authors: S Curry; E Fry; W Blakemore; R Abu-Ghazaleh; T Jackson; A King; S Lea; J Newman; D Stuart
Journal: J Virol Date: 1997-12 Impact factor: 5.103

2. Antigenic heterogeneity of a foot-and-mouth disease virus serotype in the field is mediated by very limited sequence variation at several antigenic sites.

Authors: M G Mateu; J Hernández; M A Martínez; D Feigelstock; S Lea; J J Pérez; E Giralt; D Stuart; E L Palma; E Domingo
Journal: J Virol Date: 1994-03 Impact factor: 5.103

Crystallization and preliminary X-ray analysis of three serotypes of foot-and-mouth disease virus.

1. Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus.

2. Antigenic heterogeneity of a foot-and-mouth disease virus serotype in the field is mediated by very limited sequence variation at several antigenic sites.

3. The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex.

4. Viral RNA modulates the acid sensitivity of foot-and-mouth disease virus capsids.

5. Productive Entry of Foot-and-Mouth Disease Virus via Macropinocytosis Independent of Phosphatidylinositol 3-Kinase.