| Literature DB >> 1335296 |
P Youinou1, M Buisson, J M Berthelot, C Jamin, P Le Goff, O Genoulaz, A Lamour, P M Lydyard, J M Seigneurin.
Abstract
We have examined serum antibodies to Epstein-Barr virus Nuclear Antigen (EBNA)-1, -2A and -2B, in addition to antibodies to viral capsid antigen and early antigen in 100 rheumatoid arthritis patients and 50 of their relatives. Using indirect immunofluorescence on transfected cells and Western-blot technique, we have found increased frequency and titres of antibodies to EBNA-2B in patients and, to a lesser degree, in their family members, whereas other anti-Epstein-Barr virus antibodies appeared to be similar to controls. Cross-inhibition experiments were carried out and show that antibodies to EBNA-2A are distinct from those to -2B, and vice versa.Entities:
Mesh：
Substances：
Year: 1992 PMID： 1335296 DOI： 10.3109/08916939209004828
Source DB: PubMed Journal: Autoimmunity ISSN： 0891-6934 Impact factor: 2.815